Trials Sponsors Conditions Drugs Pricing

Conditions

Keywords

StrokeOral healthSalivary biomarkersCerebrovascular diseaseObservational studyStreptococcus mutansCnm-positive Streptococcus mutansCnm geneOral microbiota

Outcome Measures

Primary Outcomes (1)

Differences in salivary inflammatory biomarker profiles between stroke patients and healthy controls.
Assessment of salivary inflammatory and neuroendocrine biomarkers, including salivary cortisol and selected inflammatory cytokines (e.g., IL-6 and/or hs-CRP), to identify biomarker patterns associated with stroke.
Single time-point assessment at enrollment

Secondary Outcomes (3)

Exploratory association between oral microbiota profiles and stroke status
Single time-point assessment at enrollment
Association between salivary Cnm-positive Streptococcus mutans and stroke status
Single time-point assessment at enrollment
Functional outcome at 90 days after stroke
90 days after stroke

Study Arms (2)

Stroke group

Patients diagnosed with stroke.

Healthy control group

Healthy participants without a history of stroke.

Eligibility Criteria

Age18 Years - 90 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients will be recruited from multiple regions within Algeria, reflecting a diverse national population.

You may qualify if:

Adults aged 18 to 90 years.

Sponsors & Collaborators

University Hospital Center (CHU) of Constantine, Algeria
Governmentlead

Study Sites (2)

Private Dental Clinic, Constantine

Constantine, 25000, Algeria

University Hospital Center (CHU) of Constantine

Constantine, 25017, Algeria

Boubekeur seddik Fekraoui, ProfessorCONTACT0559375365 neurology.departement25@gmail.com

Related Publications (1)

Miyatani F, et al. Collagen-binding activity of Streptococcus mutans and cerebral microbleeds. Stroke. 2015.
BACKGROUND

Biospecimen

Retention: SAMPLES WITH DNA

Unstimulated saliva samples will be collected for the analysis of inflammatory and biochemical biomarkers and oral bacterial DNA. Molecular analysis will include detection of Streptococcus mutans and the cnm gene using PCR/qPCR.

MeSH Terms

Conditions

StrokeCerebrovascular Disorders

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesVascular DiseasesCardiovascular Diseases

Study Officials

Abdeldjalil Zitouni, DDS
Independent Researcher, Constantine, Algeria
PRINCIPAL INVESTIGATOR

Central Study Contacts

Abdeldjalil Zitouni, DDS

CONTACT

+213550400202 djalil007_dz@yahoo.fr

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER GOV
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

January 13, 2026

First Posted

January 21, 2026

Study Start

December 20, 2026

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Primary Completion

June 2027

Oral and Salivary Biomarkers Associated With Stroke

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

Stroke group

Healthy control group

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

Related Publications (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (3)

Study Arms (2)

Stroke group

Healthy control group

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (2)

Related Publications (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations