Assessing the Effect of an Antioxidant-Rich Diet on Metabolic Syndrome Risk Using the Dietary Antioxidant Index

NCT07354438 | Recruiting

• 1 other identifier: UniversityVAS3
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

Metabolic syndrome (MetS) is a cluster of metabolic disorders characterized by elevated levels of blood glucose, hypertension, dyslipidemia, and abdominal obesity. Globally, it is a major public health concern. International studies have linked higher Dietary Antioxidant Index with reduced risk of MetS, as antioxidants play a role in lowering the risk of MetS by reducing oxidative stress, a key contributor to its pathophysiology. Exploring this link in Pakistan can provide valuable insights for dietary strategies to reduce the risk of MetS.

Conditions

Metabolic Syndrome Risk Factors

Keywords

Antioxidants; Dietary antioxidant index; Metabolic Syndrome risk

Outcome Measures

Primary Outcomes (2)

• Change in Dietary Antioxidant Index (DAI)

  DAI will be calculated from 24-hour dietary recalls to quantify total antioxidant intake. The primary objective is to assess whether the antioxidant-rich diet increases DAI in participants.

  Baseline and after 12 weeks of intervention

• Change in Metabolic Syndrome Risk Score

  A composite metabolic syndrome risk score will be calculated by summing standardized z-scores of waist circumference (cm), fasting blood glucose (mg/dL), systolic blood pressure (mmHg), triglycerides (mg/dL), and inversely weighted HDL-cholesterol (mg/dL) to generate a single continuous measure of overall metabolic syndrome risk.

  Baseline and after 12 weeks of intervention

Secondary Outcomes (1)

• Change in Body Composition

  Baseline and after 12 weeks of intervention

Study Arms (1)

Dietary Antioxidant Index-Based Dietary Intervention Arm

EXPERIMENTAL

Participants in this arm will receive an antioxidant-rich dietary intervention designed to improve the Dietary Antioxidant Index (DAI). The intervention includes guidance to increase intake of fruits, vegetables, whole grains, legumes, and antioxidant-rich foods while limiting pro-oxidant and ultra-processed foods. Changes in DAI and metabolic syndrome components will be assessed before and after the intervention.

Other: Antioxidant-Focused Diet Intervention

Interventions

Antioxidant-Focused Diet Intervention OTHER

This intervention specifically targets the Dietary Antioxidant Index (DAI) by increasing consumption of antioxidant-rich foods such as fruits, vegetables, whole grains, and legumes, while limiting pro-oxidant and ultra-processed foods. Unlike general healthy diet interventions, this study focuses on quantifiable antioxidant intake and its direct association with metabolic syndrome risk in urban adults.

Dietary Antioxidant Index-Based Dietary Intervention Arm

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 18-45 years
• Metabolic syndrome risk (abdominal obesity \& elevated BP as per NCEP ATP III criteria).
• Low fruit \& veg intake (\<5 serv./day) as per WHO.
• Willing to follow an intervention
• Non-pregnant or lactating
• Not diagnosed with malabsorption syndrome or chronic illness

You may not qualify if:

• Individuals \< 18 years or \> 45 years
• Not at risk of metabolic syndrome.
• Adequate intake of fruits \& veg (≥ 5 serv./day) as per WHO
• Not willing
• Pregnant or lactating
• Diagnosed with malabsorption syndrome or chronic illness

Sponsors & Collaborators

• University of Veterinary and Animal Sciences, Lahore - Pakistan: lead

Study Sites (1)

University of Veterinary & Animal Sciences, Lahore Pakistan

Lahore, Punjab Province, 54000, Pakistan

RECRUITING

Study Officials

• Qaisar Raza, Ph.D

  UNIVERSITY OF VETERINARY & ANIMAL SCIENCES, LAHORE PAKISTAN.

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anaum Javed, PG

CONTACT

+92-3040370308; anaumjaved768@gmail.com

Qaisar Raza, Ph.D

CONTACT

+92-3002479044; qaiasr.raza@uvas.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Model Details: This study uses a single-group interventional pre-post design to assess the effect of an antioxidant-rich diet on Dietary Antioxidant Index (DAI) and metabolic syndrome risk. Participants will receive an antioxidant rich dietary intervention, and changes in DAI and metabolic syndrome parameters will be measured before and after the intervention.

Study Record Dates

• First Submitted: December 17, 2025
• First Posted: January 21, 2026
• Study Start: January 1, 2026
• Primary Completion: April 1, 2026
• Study Completion: April 15, 2026
• Last Updated: January 21, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)