Single-Visit and Two-Visit Endodontic Treatments

NCT07354373 | Completed

• 1 other identifier: Ucsfendo
• Study Type: interventional
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

You are being asked to participate in this research study because you are being treated at the UCSF Graduate Endodontics department for an endodontic procedure. We are trying to determine the treatment outcomes of one v. two-visit endodontic treatments. .If you decide to continue, we would like to request your consent for a follow up period of 1 year to observe the healing of the abscess. Observation periods occur at 6 months following the completion of the root canal and at 12 months and are a part of the standard of care. We will review findings in the Axium chart, which will be recorded by the treating doctor

Conditions

Endodontic Infection; Periapical Periodontitis

Outcome Measures

Primary Outcomes (1)

• Clinical and Radiographic Healing

  The primary outcome was defined using a combined clinical and radiographic healing based on the Cone-Beam Computed Tomography Periapical Index (CBCT-PAI)

  12 months

Secondary Outcomes (1)

• Volumetric Change in Periapical Lesion Size

  12 months

Study Arms (2)

One-visit endodontic treatment

EXPERIMENTAL

In this arm, obturation will be completed using a single-cone technique after cleaning and shaping.

Other: control group

multiple visits endodontic treatment

EXPERIMENTAL

in this arm the endodontic therapy will be completed in multiple visits.

Other: Calcium Hydroxide (CH)

Interventions

Calcium Hydroxide (CH) OTHER

calcium hydroxide will be used as interim medication in the first visit and patients will return for the obturation in the second visit.

multiple visits endodontic treatment

control group OTHER

control group- no intervention

One-visit endodontic treatment

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Classified as American Society of Anesthesiologists (ASA) Class I or II
• presenting with radiographic evidence of apical periodontitis-defined as a Cone-Beam Computed Tomography Periapical Index (CBCTPAI) score of 3 or greater according to the Estrela classification

You may not qualify if:

• History of smoking
• Periodontal disease with probing depths ≥ 3 mm.
• Root fractures
• Immature apices
• Resorption
• perforations
• Inability to achieve rubber dam isolation
• Lack of informed consent

Sponsors & Collaborators

• University of California, San Francisco: lead

Study Sites (1)

University of California San Francisco School of dentistry

San Francisco, California, 94143, United States

Location

Related Publications (1)

• 1. Siqueira JF Jr, Rôças IN. Clinical implications and microbiology of bacterial persistence after treatment procedures. J Endod 2008;34:1291-1301. 2. Tait C, Camilleri J, Blundell K. Non-surgical endodontics: obturation. Br Dent J 2025;238:487-496. 3. Schwendicke F, Göstemeyer G. Cost-effectiveness of single- versus multistep root canal treatment. J Endod 2016;42:1446-1452. 4. Makanjuola JO, Umesi DC, Oderinu OH. Comparison of the incidence of flare-up and time efficiency in single-visit root canal treatment employing either rotary or manual step-back canal preparatory technique. Niger Postgrad Med J 2018;25:100-104. 5. Ricucci D, Siqueira JF Jr. Biofilms and apical periodontitis: prevalence and association with clinical and histopathologic findings. J Endod 2010;36:1277-1288. 6. Siqueira JF Jr. Reaction of periradicular tissues to root canal treatment: benefits and drawbacks. Endod Topics 2005;10:123-147. 7. Shuping GB, Ørstavik D, Sigurdsson A, Trope M. Reduction of intracanal bacteria using nickel-titanium rotary instrumentation and various medications. J Endod 2000;26:751-755. 8. Sjögren U, Figdor D, Spångberg L, Sundqvist G. The antimicrobial effect of calcium hydroxide as a short-term intracanal dressing. Int Endod J 1991;24:119-125. 9. Tronstad L, Andreasen JO, Hasselgren G, et al. pH changes in dental tissues after root canal filling with calcium hydroxide. J Endod 1981;7:17-21. 10. Ng YL, Mann V, Rahbaran S, et al. Outcome of primary root canal treatment: systematic review-Part 2. Influence of clinical factors. Int Endod J 2008;41:6-31. 11. Mergoni G, Ganim M, Lodi G, et al. Single versus multiple visits for endodontic treatment of permanent teeth. Cochrane Database Syst Rev 2022;12:CD004450. 12. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. J Pharmacol Pharmacother 2010;1:100-107. 13. Estrela C, Bueno MR, Azevedo BC, et al. A new periapical index based on cone-beam computed tomogr

  BACKGROUND

MeSH Terms

Conditions

Periapical Periodontitis

Interventions

Calcium Hydroxide; Control Groups

Condition Hierarchy (Ancestors)

Periapical Diseases; Jaw Diseases; Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Periodontitis

Intervention Hierarchy (Ancestors)

Hydroxides; Alkalies; Inorganic Chemicals; Calcium Compounds; Anions; Ions; Electrolytes; Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: January 21, 2026
• Study Start: September 1, 2021
• Primary Completion: July 1, 2023
• Study Completion: July 1, 2025
• Last Updated: January 21, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)