Effect of Kinesio Tape Versus Systemic Dexamethasone on Postsurgical Sequels Following Extraction of Impacted Mandibular Third Molars

NCT07353593 | Completed Phase 1 DMC

• 1 other identifier: M0208023os
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The surgical removal of lower wisdom teeth is a common procedure that can cause pain, facial swelling, and difficulty in opening the mouth after surgery. These symptoms are usually managed with medications such as dexamethasone, which helps reduce inflammation but may have unwanted side effects in some patients. This study compares the use of dexamethasone with Kinesio Tape, a non-drug treatment applied to the skin, to evaluate their effectiveness in reducing pain, swelling, and limited mouth opening after wisdom tooth removal. The findings of this study may help determine whether Kinesio Tape can be a safe and effective alternative to medication for improving recovery after surgery.

Conditions

Impacted Mandibular Third Molar Extraction

Keywords

Kinesio Tape, Dexamethasone, Mandibular Third Molar, Oral Surgery, Postoperative Edema, Pain Management, Trismus, Non-Pharmacological Therapy

Outcome Measures

Primary Outcomes (3)

• Facial swelling (edema) measured in millimeters at three facial points after mandibular third molar extraction

  Edema will be assessed using a flexible ruler at three standardized points: 1. Lateral corner of the eye to angle of the mandible 2. Tragus to corner of the mouth 3. Inferior point of the angle of the mandible to lateral point of the lip commissure Measurements will be performed immediately after extraction, at 3 days, and at 7 days postoperatively.

  Immediately after extraction, Day 3, and Day 7 postoperatively

• Maximum interincisal distance (mm) to assess mouth opening after mandibular third molar extraction

  Mouth opening will be measured as the maximum interincisal distance using a caliper. Measurements will be taken immediately after extraction, at 3 days, and at 7 days postoperatively.

  Immediately after extraction, Day 3, and Day 7 postoperatively

• Pain intensity score after mandibular third molar extraction measured using the Visual Analog Scale (VAS, 1-10)

  Pain intensity will be self-reported by each participant using the Visual Analog Scale (VAS) ranging from 1 (no pain) to 10 (worst pain imaginable). Pain will be assessed immediately post-extraction, at 3 days, and at 7 days postoperatively.

  Immediately after extraction, Day 3, and Day 7 postoperatively

Study Arms (3)

Kinesio Tape

EXPERIMENTAL

Other: Kinesio Tape application

Dexamethasone

ACTIVE COMPARATOR

Drug: Intramuscular Injection of Dexamethasone

Control

ACTIVE COMPARATOR

Other: control

Interventions

Kinesio Tape application OTHER

Kinesio Tape application after horizontal impacted mandibular third molar extraction

Kinesio Tape

Intramuscular Injection of Dexamethasone DRUG

8 M.g Intramuscular Injection of Dexamethasone\*\* after horizontal impacted mandibular third molar extraction

Dexamethasone

control OTHER

left to heal without use of Dexamethasone nor Kinesio Tape after horizontal impacted mandibular third molar extraction

Control

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients (male and female) with age 20-40 years old.
• Co-operative patients.
• An impacted lower wisdom tooth diagnosed with a moderate to severe difficulty index according to Pell and Gregory or Pederson scale classification.104
• Medically Free from any systemic conditions.

You may not qualify if:

• Uncooperative patients.
• Smoker patients.
• Pregnant or lactating women.
• Women taking oral contraceptives.
• Patient with systemic diseases.
• Patients misunderstanding the clinical procedures of the study.
• Individuals allergic or intolerant to Dexamethasone used in the study.
• Patients on oral anticoagulants.
• Uncontrolled diabetic patients.
• Individuals with periodontal disease or active infection at the site of impacted tooth.

Sponsors & Collaborators

• Ashraf elanzy: lead
• Mansoura University: collaborator

Study Sites (1)

Mansura Universtiy

Al Mansurah, Mansura, 14323, Egypt

Location

MeSH Terms

Conditions

Agnosia; Trismus

Condition Hierarchy (Ancestors)

Perceptual Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Spasm; Neuromuscular Manifestations

Study Officials

• Mohamed Abdelmonem Tawfik, Prof

  Mansoura University

  PRINCIPAL INVESTIGATOR

• Fakhreldin Hassan Abdelrahman, PHD

  Mansoura University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator, Department of Oral and Maxillofacial Surgery

Study Record Dates

• First Submitted: December 24, 2025
• First Posted: January 20, 2026
• Study Start: October 1, 2023
• Primary Completion: September 30, 2024
• Study Completion: April 30, 2025
• Last Updated: January 20, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)