The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar

NCT07351279 | Not Yet Recruiting DMC

• 1 other identifier: ERB167/2/02-07-2024/S1 ERB
• Study Type: interventional
• Target: 56
• Locations: 1 country
• Sites: 1

Brief Summary

Surgical extraction of impacted third molar is the most common surgical procedure performed in oral and maxillofacial surgery. The immediate post operative complications after 3rd molar surgery are pain, swelling and trismus while delayed post operative complications are mostly seen on the distal surface of second molar due to distal bone loss which include prolonged sensitivity due to increased periodontal pocket depth, gingival recession and root exposure. When PRF clot is given in wound, it causes alterations of the cellular ratios in the wound blood clot, leading to replacement of blood cells with Platelets and growth factors stimulating all phases of healing which will improve the immidiate and delayed post operative complications The purpose of present study is to compare the clinical outcomes in the treatment of senstivity and periodontal pockets at the distal aspect of second molar following surgical extraction of impacted third molar using PRF or Blood clot alone.

Conditions

Third Molar Impaction; Surgical Extraction of Impacted Third Molars

Outcome Measures

Primary Outcomes (3)

• Periodontal Pocket Depth

  Periodontal pocket depth will be measured as a distance between gingival margin and base of the periodontal pocket in millimeters by Williams periodontal probe .

  From Enrollment to end of treatment at 03 months

• Senstivity

  Response of patient elicited by painful stimulus i.e Tactile stimulus which is characteristically of short duration will be measured by Tactile method i.e. scratching the distal surface of second molar at cemento-enamel junction with dental explorer on Numeric scale with values from 0 to 10, 0 being the least/no sensitivity and 10 being the worst

  from Enrollment to end of treatment at 03 months

• Clinical attachment loss

  Clinical attachment loss will be measured as a distance between cemento-enamel junction of second molar to the base of periodontal pocket in millimeters by williams periodontal probe

  From Enrollment to end of treatment at 03 months

Study Arms (2)

Case Group

EXPERIMENTAL

PRF placement in extraction socket

Other: Platelet rich fibrin

Control Group

NO INTERVENTION

Surgical extraction without using PRF

Interventions

Platelet rich fibrin OTHER

After surgical extraction of impacted mandibular 3rd molar PRF will be placed in extraction socket

Also known as: PRF

Case Group

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Impacted third molar (as per Operational Definition) with fully erupted second molars bilaterally.
• Impacted Third molar with Class 2 and Level B according to Pell and Gregory's classification (Annexure B) with mesioangular or horizontal angulation of impaction
• Periodontal pocket depth \> 4mm and Clinical attachment loss \> 1mm at distal side of second molar
• Age 18-40 years, both genders.
• Patients who give informed consent.

You may not qualify if:

• Any Systemic Disease i.e. Uncontrolled Diabetes mellitus, Uncontrolled hypertension, Ischemic heart disease, bleeding disorders, Autoimmune diseases or immunocompromised patients
• Decayed or recommended for extraction second molars on either side.
• Allergic to Amoxicillin to standardize Antibiotic therapy protocol.
• Untreated periodontal condition.
• Inability to follow up.

Sponsors & Collaborators

• University of Health Sciences Lahore: lead

Study Sites (1)

Allama Iqbal Medical College/ Jinnah Hospital

Lahore, Punjab Province, 54000, Pakistan

Location

Related Publications (11)

• Tadić, A., Bajkin, B., Mijatov, I., Mirnić, J., Vukoje, K., Sokač, M. And Vukelić, D., 2023. Influence of L-PRF topical application on bone tissue healing after surgical extraction of impacted mandibular third molars: A randomized split-mouth clinical study. Applied Sciences, 13, 4823.

  BACKGROUND

• Sybil D, Sawai M, Faisal M, Singh S, Jain V. Platelet-Rich Fibrin for Hard- and Soft-Tissue Healing in Mandibular Third Molar Extraction Socket. Ann Maxillofac Surg. 2020 Jan-Jun;10(1):102-107. doi: 10.4103/ams.ams_228_19. Epub 2020 Jun 8.

  PMID: 32855924 BACKGROUND

• Swetha Bhat, B., Periasamy, S. And Arun, M., 2021. Incidence of residual periodontal defects distal to second molar due to a mesioangular mandibular impacted third molar. International Journal of Dentistry and Oral Science, 8(7), pp. 3119-3123.

  BACKGROUND

• Roy, I.D., Saxena, V., Babu, B.K.N. and Perumal, S.J., 2021. Efficacy of platelet-rich fibrin on pain, edema, and healing in mandibular third molar surgery: A split-mouth randomized study. Journal of Dental Defence Section, 15, pp. 21-30.

  BACKGROUND

• Rocha MOC, Cruz AACF, Santos DO, Douglas-DE-Oliveira DW, Flecha OD, Goncalves PF. Sensitivity and specificity of assessment scales of dentin hypersensitivity - an accuracy study. Braz Oral Res. 2020 May 8;34:e043. doi: 10.1590/1807-3107bor-2020.vol34.0043.

  PMID: 32401933 BACKGROUND

• Malhotra A, Kapur I, Das D, Sharma A, Gupta M, Kumar M. Comparative evaluation of bone regeneration with platelet-rich fibrin in mandibular third molar extraction socket: A randomized split-mouth study. Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):241-247. doi: 10.4103/njms.NJMS_50_19. Epub 2020 Dec 16.

  PMID: 33897188 BACKGROUND

• Lam, C.P., Nguyen, T.B.N. and Nguyen, T.B.L., 2023. Effect of platelet-rich fibrin on soft tissue, periodontal pocket healing, and alveolar bone height after third molar surgery: A randomized clinical trial. Scholars Journal of Dental Sciences, 10(7), pp. 121-127.

  BACKGROUND

• Gasparro R, Sammartino G, Mariniello M, di Lauro AE, Spagnuolo G, Marenzi G. Treatment of periodontal pockets at the distal aspect of mandibular second molar after surgical removal of impacted third molar and application of L-PRF: a split-mouth randomized clinical trial. Quintessence Int. 2020;51(3):204-211. doi: 10.3290/j.qi.a43947.

  PMID: 32020130 BACKGROUND

• Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. J Clin Periodontol. 2017 Jan;44(1):67-82. doi: 10.1111/jcpe.12643. Epub 2016 Nov 24.

  PMID: 27783851 BACKGROUND

• Bhujbal, R., Veerabhadrappa, S.K., Yadav, S., Chappi, M. And Patil, V., 2020. Evaluation of platelet-rich fibrin and platelet-rich plasma in impacted mandibular third molar extraction socket healing and bone regeneration: A split-mouth comparative study. European Journal of General Dentistry, 9, pp. 96-102.

  BACKGROUND

• Abad CE, Sanz-Sanchez I, Serrano V, Sanz Esporrin J, Sanz-Martin I, Sanz M. Efficacy of the application of leukocyte and platelet-rich fibrin (L-PRF) on alveolar ridge preservation. A randomized controlled clinical trial. Clin Implant Dent Relat Res. 2023 Jun;25(3):592-604. doi: 10.1111/cid.13208. Epub 2023 Apr 23.

  PMID: 37088697 BACKGROUND

Central Study Contacts

MHayat

CONTACT

+923420690087; uhayat722@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PGR OMFS( MDS)

Model Details: Split mouth randomized, Controlled clinical trial

Study Record Dates

• First Submitted: January 11, 2026
• First Posted: January 20, 2026
• Study Start: February 1, 2026
• Primary Completion (Estimated): July 1, 2027
• Study Completion (Estimated): February 1, 2028
• Last Updated: January 20, 2026

Record last verified: 2026-01

Locations

PA (1)