Impact of Regular Low-Frequency Hemoperfusion on Medium- to Long-Term Prognosis in Maintenance Dialysis Patients

NCT07348913 | Completed

• 1 other identifier: Chong qing Medical University
• Study Type: observational
• Target: 879
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To investigate the effect of regular low-frequency hemoperfusion on all-cause mortality and cardiovascular/cerebrovascular mortality risk in maintenance hemodialysis (MHD) patients. Methods: Data from MHD patients over the past 10 years at our blood purification center were retrospectively collected. Patients were divided into a hemoperfusion group (receiving regular low-frequency hemoperfusion once monthly) and a non-hemoperfusion group. Propensity score matching (PSM) was used to balance baseline characteristics. Differences in cumulative all-cause and cardiovascular/cerebrovascular mortality between the two groups before and after matching were compared. A competing risk model was employed to analyze mortality risk.

Conditions

Regular Low-Frequency Hemoperfusion; Medium- to Long-Term Prognosis; Maintenance Dialysis Patients; Retrospective Study

Keywords

Hemoperfusion; Maintenance Dialysis; Propensity Score Matching; Survival Analysis; Competing Risk; Cardiovascular/Cerebrovascular Death

Outcome Measures

Primary Outcomes (2)

• Cardiovascular/Cerebrovascular Death

  1, 3, 5, and 10 years

• all-cause mortality

  1, 3, 5, and 10 years

Study Arms (2)

hemoperfusion group

receive regular low-frequency hemoperfusion once monthly

non-hemoperfusion group

not receive regular low-frequency hemoperfusion once monthly

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who received MHD treatment at the Hemodialysis Center of the First Affiliated Hospital of Chongqing Medical University from January 2015 to December 31, 2024. Included patients were aged ≥18 years, received dialysis three times a week (each session lasting 3-4 hours), had basically complete clinical and laboratory records, and were followed up at our center for at least 6 months.

You may qualify if:

• Included patients were aged ≥18 years
• Undergo dialysis treatment three times a week (each session lasting 3-4 hours)
• Having basically complete clinical and laboratory records, and having received at least 6 months of follow-up at this center

You may not qualify if:

• Under 18 years old
• Does not receive dialysis three times a week (each session lasts 3-4 hours)
• Does not have basic complete clinical and laboratory records, and has not been followed up at this center for at least 6 months

Sponsors & Collaborators

• Yunfeng Xia: lead

Study Sites (1)

First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Chief Physician of Nephrology、Clinical Professor

Study Record Dates

• First Submitted: December 29, 2025
• First Posted: January 16, 2026
• Study Start: January 1, 2015
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: January 16, 2026

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)