Effect of Blood Flow Restriction Training Exercises on Hand Grip Strength in Hemiparetic Cerebral Palsied Children

NCT07347795 | Not Yet Recruiting

• 1 other identifier: P.T.REC/012/005952
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to investigate the effect of blood flow restriction (BFR) training exercises on the hand grip strength of children with hemiparetic cerebral palsy. Hand grip strength is a vital component of motor function and is often severely compromised in children with hemiparetic CP, which can significantly impact their daily activities and quality of life. Blood flow restriction (BFR) training is a novel exercise technique where a cuff or band is used to partially occlude blood flow during low-intensity resistance exercises. This method has been shown to stimulate muscle growth and strength gains similar to those achieved through high-intensity strength training, without the need for high loads. Given the unique physiological challenges faced by children with hemiparetic CP, BFR training could provide an effective alternative to traditional strength training methods.

Conditions

Cerebral Palsy Spastic Hemiplegic

Outcome Measures

Primary Outcomes (2)

• Hand grip strength measured using a handheld dynamometer

  Hand grip strength of the affected hand will be assessed using a calibrated handheld dynamometer. The maximum voluntary grip force will be recorded in kilograms (kg). Three trials will be performed, and the highest value will be used for analysis.

  8 weeks

• muscle thickness at the midpoint of the forearm flexor muscles

  8 weeks

Study Arms (2)

Control group

ACTIVE COMPARATOR

The control group performs traditional hand grip strengthening exercises, focusing on similar exercises but without blood flow restriction. Both groups participate in a similar frequency and duration of training, with a gradual increase in repetitions over the 8 weeks

Behavioral: control group

Study group

EXPERIMENTAL

Device: Blood Flow Restriction Training Exercises group

Interventions

Blood Flow Restriction Training Exercises group DEVICE

The BFR group underwent BFR training for 8 weeks, with sessions held three times per week. A tourniquet-style cuff is placed on the upper arm to restrict blood flow during exercise. The exercises involved are low-intensity grip strengthening activities (e.g., squeezing a rubber ball, gripping a hand dynamometer) at 20% of their one-repetition maximum (1RM). The cuff pressure is set at 50-70% of the participants' limb occlusion pressure, as determined by an initial assessment.

Study group

control group BEHAVIORAL

The control group performs traditional hand grip strengthening exercises, focusing on similar exercises but without blood flow restriction. Both groups participate in a similar frequency and duration of training, with a gradual increase in repetitions over the 8 weeks.

Control group

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Age will range from 6-12 years
• Diagnosed with hemiparetic cerebral palsy (right or left side).
• According to Modified Ashwer scale, has grade 1 or 1+ grade
• Children with the ability to understand and follow verbal commands and instructions used during training and tests

You may not qualify if:

• Any contraindications to exercise, such as moderate or severe spasticity, orthopedic deformities, or other serious health conditions.

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo Universit

Giza, Egypt

Location

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Central Study Contacts

Alsakhawi

CONTACT

00966504182628; rsm211_pt@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 31, 2025
• First Posted: January 16, 2026
• Study Start: February 20, 2026
• Primary Completion: May 1, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: February 4, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)