Study on the Accuracy of Determining the Responsible Vessel in Medium Vessel Occlusive Stroke Based on Multi-type CT Evaluation

NCT07347587 | Recruiting

• 1 other identifier: XMEC-2025-001
• Study Type: observational
• Target: 622
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the accuracy of diagnosing the qualifying artery in patients with medium vessel occlusion stroke based on multimodal CT

Conditions

Stroke

Keywords

medium vessel occlusion; Multimodal CT; CTP

Outcome Measures

Primary Outcomes (1)

• The difference in accuracy between the evaluation of MeVO stroke using multimode CT and that using NCCT+CTA

  The difference in accuracy between the evaluation of MeVO stroke using multimode CT and that using NCCT+CTA

  at baseline

Secondary Outcomes (2)

• The time required by the reader to identify the qualifying artery before and after using CTP

  at baseline

• The consistency between the core infarction volume evaluated based on CTP and the final infarction volume obtained from MRI examination within 7 days after the onset

  7 days after the onset

Study Arms (2)

NCCT+CTA group

The attending physicians of neurology (with more than 5 years of experience in neuroimaging interpretation and not relevant to this study), without knowing the final radiological report, DSA, MRI results and clinical manifestations, only used baseline non-contrast CT (NCCT) and CTA to determine whether the included cases had moderate vascular occlusion. And record the qualifying artery

NCCT+CTA+CTP group

The attending physicians of neurology (with more than 5 years of experience in neuroimaging interpretation and not relevant to this study), without knowing the final radiological report, DSA, MRI results and clinical manifestations, only used baseline non-contrast CT (NCCT) , CTA and CTP to determine whether the included cases had moderate vascular occlusion. And record the qualifying artery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

According to previous literature reports, the prevalence of MeVO stroke accounts for 18% of ischemic stroke. It is estimated that the sensitivity of NCCT + CTA in diagnosing MeVO is 74%. Based on multimodal CT, the sensitivity for diagnosing moderate vascular occlusive stroke can be increased by 15%, reaching 89%. The test level is bilateral 0.05, and the confidence level 1 - β = 0.8. Then, at least 622 research subjects are required. Among them, the number of patients with MeVO, N1 = 622 \* 0.18 = 112 cases.

You may qualify if:

• Patients with acute ischemic stroke, without restrictions on gender
• Age ≥ 18 years old
• The time from onset to treatment is within 24 hours (the onset time is defined as the "last-well-time", and the treatment plan is determined according to the patient's wishes and local clinical experience)
• Before the treatment, CT, CTA and CTP examinations were conducted, and the relevant clinical data were complete.

You may not qualify if:

• Patients with acute intracranial hemorrhage
• Patients whose CTP original images cannot be processed by the CTP post-processing software
• Patients for whom the DICOM format image data of CT, CTP original images and MRI images cannot be obtained, or whose image quality is poor due to various reasons

Sponsors & Collaborators

• Xuanwu Hospital, Beijing: lead
• Beijing Hospitals Authority: collaborator

Study Sites (1)

Xuanwu Hospital Capital Medical University

Beijing, Beijing Municipality, 100053, China

RECRUITING

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Shujuan Meng, MD

CONTACT

01083198082; 1026012717@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 9, 2026
• First Posted: January 16, 2026
• Study Start: March 13, 2025
• Primary Completion: March 13, 2026
• Study Completion: March 13, 2026
• Last Updated: January 16, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)