Large Language Model for Understanding and Monitoring Elderly Neurocognition

NCT07347431 | Recruiting

• 1 other identifier: NHCT0571
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Dementia affects millions of people worldwide, and early diagnosis is essential for getting the right care and support. Doctors rely on collateral histories (accounts from family members or caregivers) to understand changes in a person's memory and thinking. However, these histories can be incomplete, unstructured, or difficult to obtain, making diagnosis more challenging. This study will test LUMEN (Large Language Model for Understanding and Monitoring Elderly Neurocognition), an AI-powered conversation tool designed to help caregivers describe their loved one's symptoms more effectively. By asking structured questions and guiding the conversation, LUMEN can create clear, well-organised reports for memory clinic doctors. This could make assessments quicker, more accurate, and less stressful for families. We will test LUMEN in real-world clinics by asking caregivers and doctors to use it and provide feedback. We want to understand how easy it is to use, whether it could improve the quality of information shared, and how it fits into existing NHS memory clinic processes. We will also run co-production workshops with community groups to ensure the tool is accessible to people from diverse cultural and language backgrounds. This research is exciting because it explores how artificial intelligence can improve dementia care. If successful, LUMEN could enhance the diagnostic process, reduce carer burden, and help more people access dementia support sooner. In the future, this tool could be used nationwide in memory clinics, improving care for thousands of families.

Conditions

Dementia

Keywords

Dementia; Alzheimer's Disease; Artificial Intelligence; Large Language Models

Outcome Measures

Primary Outcomes (2)

• SUS (System Usability Scale)

  10-item Likert-scale questionnaire assessing ease of use (score ≥70 = good usability).

  Immediately after use of software

• NASA-TLX (Task Load Index):

  Evaluates perceived cognitive workload (scores 0-29 = low workload).

  Immediately after prototype interaction

Other Outcomes (1)

• Thematic analysis

  1-10 days after use of prototype software

Study Arms (2)

Patient-carer dyads

Carers (n=20-30 dyads): Recruited via Northumbria NHS Memory Clinics. Eligible carers will be adults (≥18 years) who know the patient well, have basic English literacy, and can provide informed consent. • Patients (n=20-30): Individuals (≥65 years) attending a memory clinic for cognitive assessment. 1. Baseline Data Collection: * Demographics (age, gender, ethnicity, socioeconomic status). * Clinical diagnosis (where available). * Cognitive test scores (MoCA/ACE). 2. LUMEN Interaction: o Carers will use LUMEN on a laptop or tablet to provide structured collateral histories (\~20-30 min). 3. Usability and Cognitive Load Assessment: * SUS (System Usability Scale): 10-item Likert-scale questionnaire assessing ease of use (score ≥70 = good usability). * NASA-TLX (Task Load Index): Evaluates perceived cognitive workload (scores 0-29 = low workload). 4. Qualitative Evaluation: * Semi-structured interviews (n=10 carers).

Other: LUMEN prototype software interaction

Clinicians

4.1. Participants and Recruitment • Clinicians (n=8-10): Specialists in dementia care (neurologists, psychiatrists, geriatricians, advanced nurse practitioners) with ≥2 years of experience. 4.2. Study Procedures 1. Baseline Data Collection: o Demographics (age, gender, ethnicity, socioeconomic status). 2. LUMEN Interaction: o Clinicians will review LUMEN-generated histories to assess completeness and clinical utility. 3. Usability and Cognitive Load Assessment: * SUS (System Usability Scale): 10-item Likert-scale questionnaire assessing ease of use (score ≥70 = good usability). * NASA-TLX (Task Load Index): Evaluates perceived cognitive workload (scores 0-29 = low workload). 4. Qualitative Evaluation: * Semi-structured interviews (n=4-5 clinicians).

Other: LUMEN prototype software interaction

Interventions

LUMEN prototype software interaction OTHER

This is a prototype software which seeks to gather collateral information relevant to a dementia clinical assessment.

Clinicians; Patient-carer dyads

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient and carer dyads: patients attending the Memory Clinic for assessment of cognitive problems. Clinicians: specialist doctors or advanced nurse practitioners responsible for dementia diagnosis

Carers of patients attending Memory Clinic appointments; Aged 18 or over; Both patients and cares can provide informed consent; Basic English literacy Clinicians must have at least 2 years of specialist dementia care experience and be personally responsible for dementia diagnosis; Must be provide informed consent

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Northumbria Healthcare NHS Foundation Trust: lead
• Newcastle University: collaborator

Study Sites (1)

North Tyneside General Hospital is Rake Lane

North Shields, NE29 8NH, United Kingdom

RECRUITING

Related Links

• Related Info

MeSH Terms

Conditions

Dementia; Alzheimer Disease

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases

Study Officials

• Judith R Harrison, MBChB PhD

  Northumbria Healthcare NHS Foundation Trust

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Judith R Harrison, MBChB

CONTACT

+441912081314; Judith.Harrison@newcastle.ac.uk

Lisa Gallagher

CONTACT

+44191 293 4087; Lisa.gallagher@northumbria-healthcaretrust.nhs.uk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 8, 2026
• First Posted: January 16, 2026
• Study Start: March 19, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 21, 2026

Record last verified: 2026-03

Locations

GB (1)