NCT07347119|Not Yet Recruiting
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Sponsor study identifier
observational
120
1 country
1
Study Start
December 18, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
By leveraging parameters including fractal dimension and topological index, we constructed a quantitative evaluation framework for ultra-widefield optical coherence tomography angiography (UWF-OCTA) images in patients with central serous chorioretinopathy (CSC), thus overcoming the limitations of conventional qualitative analysis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 17, 2025
Actual (reported)December 18, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
January 16, 2026
Actual (reported)June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Choroidal Vascular Fractal Dimension
Choroidal vascular fractal dimension quantified from optical coherence tomography angiography (OCTA) images.
Baseline, 1 month, 3 months, 6 months, and 12 months
Maximum subretinal fluid height
Baseline, 1 month, 3 months, 6 months, and 12 months
Subretinal fluid area
Baseline, 1 month, 3 months, 6 months, and 12 months
Subretinal fluid volume
Baseline, 1 month, 3 months, 6 months, and 12 months
Choroidal vascular branching index
Baseline, 1 month, 3 months, 6 months, and 12 months
Choroidal Vascular Connectivity Index
Baseline, 1 month, 3 months, 6 months, and 12 months
Clinically, serous retinal detachment (SRD) can be detected via fundus examination and optical coherence tomography (OCT), along with focal or multifocal retinal pigment epithelium (RPE) changes confined to small pigment epithelial detachment (PED) lesions. Fundus fluorescein angiography (FFA) demonstrates RPE leakage. SRD typically resolves within 3-4 months, and in most cases, no long-term symptoms persist except for color discrimination deficits in some patients.
When the disease course exceeds 4-6 months, obvious multifocal atrophic retinal pigment epithelium (RPE) changes, multifocal leakage, and extensive RPE atrophy can be observed. Fundus autofluorescence (FAF) shows hypofluorescence in the RPE-damaged areas.
The patient has a history of one or more previous episodes, during which the symptoms completely resolved or significantly improved, and optical coherence tomography (OCT) examination showed complete absorption of subretinal fluid, with reattachment of the neurosensory retina. After complete remission of the first (or previous) episode (an interval of at least 3-6 months is generally considered), the patient develops typical symptoms of central serous chorioretinopathy (CSC) again, accompanied by objective evidence of the acute or chronic phase, such as changes detected by OCT or fundus fluorescein angiography (FFA).
Healthy control subjects without any local or systemic diseases
The study subjects were recruited from outpatients of the Medical Retina Department at Zhongshan Ophthalmic Center, and eligible cases meeting the study criteria were selected from the outpatient medical record system.
Zhongshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, 510060, China
Chenjin Jin, PH.D
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong 510060
First Submitted
December 17, 2025
First Posted
January 16, 2026
Study Start
December 18, 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy
Contact the study team to confirm eligibility.
June 30, 2027
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 30, 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
January 16, 2026
Record last verified: 2026-01
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