Reversal of Roux-en-Y Gastric Bypass: A Swedish National Cohort Study

NCT07347093 | Active Not Recruiting

• 1 other identifier: Dnr 2022-01827-01
• Study Type: observational
• Target: 199
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: To investigates incidence, indications, symptom relief, complications, and weight outcomes after Roux-en-Y gastric bypass (RYGB) reversal. Background: RYGB is an effective treatment for obesity, but in rare cases may be associated with severe long-term complications requiring RYGB reversal. Evidence on incidence and outcomes is limited. Methods: This nationwide, multi-center, retrospective cohort study included all patients undergoing RYGB reversal in Sweden between 2007 and 2023. Data were obtained from the Scandinavian Obesity Surgery Registry (SOReg) and medical records.

Conditions

Gastric Bypass Surgery; Revisional Bariatric Surgery; Complications After Bariatric Surgery

Keywords

Roux-en-Y gastric bypass; Anatomical reversal; Indications; Complications; Outcomes

Outcome Measures

Primary Outcomes (1)

• Symptom relief

  Symptom relief is classified as no, partial, or complete improvement. Complete improvement was defined as full resolution of the index symptom (e.g., cessation of hypoglycemia, pain-free status without analgesics). Partial improvement denoted a clinically meaningful reduction in symptom severity or frequency that did not meet criteria for complete resolution. No improvement indicated persistent symptoms.

  Through study completion, an average of 2 years.

Secondary Outcomes (5)

• Indications for surgery

  Through study completion, an average of 2 years.

• Weight outcome after surgery

  Through study completion, an average of 2 years.

• Complications

  At 30-day follow-up and one-year follow-up after surgery.

• Height

  Through study completion, an average of 2 years

• BMI

  Through study completion, an average of 2 years.

Other Outcomes (1)

• Surgical technique

  Perioperative/periprocedural

Study Arms (1)

Adults (≥ 18years) who underwent reversal of RYGB

Included patients were adults (≥ 18years) who underwent reversal of RYGB between 2007 and 2023. Exclusion criteria included emergency reversal due to bowel ischemia, reversal following other bariatric procedures (e.g. gastric banding), or partial/functional reversals (e.g., gastro-gastric fistula or anastomosis between the Roux-limb and gastric remnant, without full reversal of RYGB)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

National registry-based cohort

You may qualify if:

• Adult patients (≥ 18years) who underwent reversal of RYGB between 2007 and 2023.

You may not qualify if:

• Emergency reversal due to bowel ischemia
• Reversal following other bariatric procedures (e.g. gastric banding)
• Partial/functional reversals (e.g., gastro-gastric fistula or anastomosis between the Roux-limb and gastric remnant, without full reversal of RYGB)

Sponsors & Collaborators

• Vrinnevi Hospital: lead

Study Sites (1)

Vrinnevi Hospital

Norrköping, 60182, Sweden

Location

Study Officials

• Ellen A Andersson, MD

  Department of Surgery, Vrinnevi Hospital, Norrköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, senior consultant

Study Record Dates

• First Submitted: December 16, 2025
• First Posted: January 16, 2026
• Study Start: November 1, 2025
• Primary Completion: March 31, 2026
• Study Completion (Estimated): May 31, 2026
• Last Updated: January 20, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

SE (1)