CommunityRx-Dementia + Peer Navigation (CRxDpeer)

NCT07346183 | Not Yet Recruiting

• 2 other identifiers: IRB25-1341R01AG091308
• Study Type: interventional
• Target: 330
• Locations: 0 countries
• Sites: N/A

Brief Summary

The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a "peer mentor", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of personalized community resource information for social and caregiving needs through delivery of a resource list (HealtheRx) at the baseline encounter and coaching on how to communicate with service providers, coordinate services and manage social support (e.g., connect with their peer navigator, reach out to friends or relatives for support, identify support groups, etc.) and (c) ongoing navigation-focused support meant to boost the baseline intervention, including a series of proactive text messages over 12 months. During this time, the subject can respond to and communicate with the peer navigator for ongoing support.

Conditions

Peer Support; Implementation Science; Advance Care Planning; Alzheimer s Disease; Dementia; Caregiver; Loneliness; Health-Related Social Needs; Social Care; Caregiver Burden; Anxiety; Stress; Depression; Healthcare Utilization; End of Life Care; Self-Efficacy

Keywords

resource navigation; peer navigator; peer mentor; social care; dementia caregiver

Outcome Measures

Primary Outcomes (2)

• Caregiver loneliness at 6 months

  Loneliness is measured using the 3-item UCLA Loneliness Scale (Hughes et al. 2004). Responses to each of the items are scored 1= "Hardly ever", 2= "Some of the time", or 3= "Often". A total score is generated by summing the individual items, with a possible range of 3-9 and higher scores = greater loneliness.

  6 months

• Caregiver's self-efficacy for finding end of life/advance care planning resources for the person with dementia at 12 months

  Self-efficacy is measured using a single item question developed for this study: "How confident are you that you can find resources to help \[name of care recipient\] put into writing their medical wishes if they were very sick or near the end of their life?". Responses are measured on a 4-point scale of 1="Not at all confident", 2="Not very confident", 3="Somewhat confident", or 4="Completely confident" \[higher score = greater self-efficacy\].

  12 months

Study Arms (2)

Cases

EXPERIMENTAL

Usual care + CommunityRx-Dpeer

Other: CommunityRx-Dpeer

Control

NO INTERVENTION

Usual Standard Care

Interventions

CommunityRx-Dpeer OTHER

Essential components of the CRxDpeer intervention include: (1) focused education about common social (e.g. food, housing, transportation) and, specifically, caregiving needs (e.g. caregiver education, stress management, End of Life/Advance Care Planning (EOL/ACP)) and related resources, (2) activation of community resources through delivery of and coaching on use of a personalized local referral list (a "HealtheRx") and (3) boosting through a series of automated proactive text messages and ongoing resource navigational support by text/phone/email/video for utilizing resources. This intervention will be delivered by a peer mentor who is experienced in dementia caregiving and trained to provide 1:1 peer mentorship and resource navigation to dementia caregivers.

Also known as: CRxDpeer

Cases

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Self-identifies as a caregiver of a home-dwelling person with Alzheimer's disease or related dementias (ADRD)
• Resides in the target geographic region of the study
• Has access to a cell phone and agrees to receive text messages from the study
• Has an email address that they can receive emails from
• Individuals under the age of 18 who are emancipated minors in the state of Illinois and a caregiver of a person with dementia

You may not qualify if:

• Minors who are not emancipated in the state of Illinois.
• Previously participated in the intervention arm of the CommunityRx-Dementia clinical trial

Sponsors & Collaborators

• University of Chicago: lead
• National Institute on Aging (NIA): collaborator

Related Publications (1)

• Hughes ME, Waite LJ, Hawkley LC, Cacioppo JT. A Short Scale for Measuring Loneliness in Large Surveys: Results From Two Population-Based Studies. Res Aging. 2004;26(6):655-672. doi: 10.1177/0164027504268574.

  PMID: 18504506 BACKGROUND

MeSH Terms

Conditions

Dementia; Caregiver Burden; Anxiety Disorders; Depression

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Stress, Psychological; Behavioral Symptoms; Behavior

Central Study Contacts

Ifeoluwadolapo Ojewuyi, MPH

CONTACT

773-704-9724; ifeoluwadolapo.ojewuyi@bsd.uchicago.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Double-Blind randomized controlled trial where the data collectors are blinded to the condition to which the subject has been assigned. The subject is also blinded to the condition they are assigned.
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Cases will receive the CRxDpeer intervention plus usual care. Controls will not receive the intervention, but will receive the usual standard of care.

Study Record Dates

• First Submitted: January 14, 2026
• First Posted: January 16, 2026
• Study Start: March 1, 2026
• Primary Completion (Estimated): February 28, 2029
• Study Completion (Estimated): February 28, 2029
• Last Updated: February 9, 2026

Record last verified: 2026-01