Panniculitis in Dermatomyositis

NCT07345949 | Recruiting

• 1 other identifier: 9944
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Adipose tissue involvement is rare in dermatomyositis. The occurrence of partial or diffuse lipodystrophy is a rare but well-characterized manifestation, particularly in juvenile forms of dermatomyositis. Panniculitis, on the other hand, is exceptional and rarely described in the literature, mostly in the form of clinical cases. Panniculitis in dermatomyositis is exceptional. There are no validated diagnostic criteria or treatment recommendations. Treatment is based, by analogy, on the therapeutic strategy for lupus panniculitis and involves synthetic antimalarials combined with steroids and/or immunosuppressants. The aim of this study is to describe panniculitis in dermatomyositis in order to determine whether there are clinical or histological characteristics that distinguish it from other causes of panniculitis, particularly panniculitis associated with lupus erythematosus.

Conditions

Panniculitis; Dermatomyositis

Keywords

Panniculitis; Dermatomyositis; Adipose tissue

Outcome Measures

Primary Outcomes (1)

• Determine the clinical and histological characteristics of panniculitis in dermatomyositis

  The investigators aim to describe: how inflammation of the subcutaneous fat manifests * in individuals with dermatomyositis * both: * clinically and visually in the patient * under the microscope (histology)

  Up to 30 months

Eligibility Criteria

• Age: 1 Year+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subject with a confirmed diagnosis of dermatomyositis and panniculitis

You may qualify if:

• Subject aged 1 year and older
• With a confirmed diagnosis of dermatomyositis
• With a confirmed diagnosis of panniculitis

You may not qualify if:

• Panniculitis for which another cause has been established, particularly infectious and metabolic panniculitis

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service de dermatologie - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Panniculitis; Dermatomyositis

Condition Hierarchy (Ancestors)

Connective Tissue Diseases; Skin and Connective Tissue Diseases; Skin Diseases; Polymyositis; Myositis; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Diseases; Nervous System Diseases

Central Study Contacts

Dan LIPSKER, MD

CONTACT

33 3 88 11 50 48; dan.lipsker@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 7, 2026
• First Posted: January 16, 2026
• Study Start: October 20, 2025
• Primary Completion (Estimated): April 1, 2028
• Study Completion (Estimated): April 20, 2028
• Last Updated: January 16, 2026

Record last verified: 2026-01

Locations

FR (1)