VCMX, PRF and SCTG Treatment in the Gingival Recessions

NCT07345520 | Completed Phase 3

• 1 other identifier: 21.12.2022/12
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Comparison of Volume-Stable Collagen Matrix, Platelet-Rich Fibrin, and Subepithelial Connective Tissue Graft in the Treatment of Multiple Adjacent Gingival Recessions: A Parallel-Group, Randomized, Controlled Clinical Trial

Conditions

Gingival Recession, Localized

Outcome Measures

Primary Outcomes (1)

• Percentage of Complete Root Coverage

  Percentage of CRC will be calculated as: (number of teeth achieving complete root coverage) ÷ (total treated teeth)\] × 100

  12 Months

Secondary Outcomes (10)

• Percentage of Mean Root Coverage

  12 months

• Recession depth

  12 month

• Probing depth

  12 months

• Clinical attachment level

  12 months

• Keratinized gingiva width

  12 months

Study Arms (3)

Volume Stable Collagen Matrix+Coronally Advanced Flap

EXPERIMENTAL

The pre-prepared Volume Stable Collagen Matrix will be moistened with saline solution (SF) and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.

Biological: Volume-Stable Collagen Matrix

Platelet-Rich Fibrin+Coronally Advanced Flap

ACTIVE COMPARATOR

Autologous platelet-rich fibrin (PRF) will be prepared from the patient's venous blood according to a standardized protocol and placed beneath a coronally advanced flap at the recipient site during periodontal surgery to enhance soft tissue healing and regeneration.

Biological: Volume-Stable Collagen Matrix

Subepithelial Connective Tissue Graft+Coronally Advanced Flap

ACTIVE COMPARATOR

A subepithelial connective tissue graft harvested from the patient's palate and placed beneath a coronally positioned flap at the recipient site during periodontal surgery.

Biological: Volume-Stable Collagen Matrix

Interventions

Volume-Stable Collagen Matrix BIOLOGICAL

Volume-Stable Collagen Matrix

Platelet-Rich Fibrin+Coronally Advanced Flap; Subepithelial Connective Tissue Graft+Coronally Advanced Flap; Volume Stable Collagen Matrix+Coronally Advanced Flap

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• ≥2 mm buccal recessions affecting ≥2 adjacent maxillary teeth;
• systemically and periodontally healthy;
• non-smokers;
• Miller Class I-II (no interproximal attachment or CEJ loss);
• probing depth (PD) \<3 mm;
• GT ≥1 mm;
• KGW ≥2 mm;
• identifiable CEJ;
• full-mouth plaque index (PI) \<20%(O'Leary et al., 1972) and gingival index (GI) score of 0(Löe, 1967) and
• vital teeth to be treated.

You may not qualify if:

• smokers;
• caries/restorations/abrasions in the treated area, furcation involvement;
• contraindications to surgery;
• pregnancy or lactation;
• medications compromising healing;
• surgery in the same region within 2 years;
• bleeding disorders;
• requirement for antibiotic prophylaxis; and
• collagen allergy.

Sponsors & Collaborators

• Bulent Ecevit University: lead

Study Sites (1)

Ankara Yıldırım Beyazit University

Ankara, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Gingival Recession

Condition Hierarchy (Ancestors)

Gingival Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Model Details: A Parallel-Group, Randomized, Controlled Clinical Trial

Study Record Dates

• First Submitted: November 23, 2025
• First Posted: January 15, 2026
• Study Start: December 1, 2022
• Primary Completion: October 1, 2024
• Study Completion: October 1, 2024
• Last Updated: January 15, 2026

Record last verified: 2026-01

Locations

TU (1)