Sarcoidosis Immunotsuppressive Therapy and Lymphoma Development

NCT07343401 | Completed DMC

• 2 other identifiers: Alexandria UAlexandria University
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Impact of Immunosuppressive Therapy for Sarcoidosis on Lymphoma Development

Conditions

Sarcoidosis Lung

Keywords

lymphoma; sarcoidosis

Outcome Measures

Primary Outcomes (2)

• The primary outcome will be incident, biopsy-proven lymphoma during the 12-month follow-up.

  LYMPH NODE BIOPSY EITHER EXCISIONAL OR BRONCHOSCOPIC

  12 MONTHS

• lymphoma development

  lymph node biopsy excisional or bronchoscopic

  12 months

Study Arms (1)

Inclusion criteria include adult patients (≥16 years) with histologically confirmed sarcoidosis, rec

This is a prospective observational cohort study to be conducted in the Chest Diseases Department, Alexandria Main University Hospital. A total of 40 adult patients (≥16 years) with biopsy-proven sarcoidosis will be consecutively recruited between December 2024 and December 2025. All patients will be either newly starting or continuing immunosuppressive therapy for sarcoidosis.

Procedure: lymph node biopsy

Interventions

lymph node biopsy PROCEDURE

sarcoidosis diagnosis by lymph node biopsy excisiona or bronchoscopic

Inclusion criteria include adult patients (≥16 years) with histologically confirmed sarcoidosis, rec

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Prospective cohort

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Alexandria main university hospital

Alexandria, Asafra, 11511, Egypt

Location

Related Links

• pubmed
• national library of diseases

MeSH Terms

Conditions

Sarcoidosis, Pulmonary; Lymphoma; Sarcoidosis

Interventions

Sentinel Lymph Node Biopsy

Condition Hierarchy (Ancestors)

Lung Diseases, Interstitial; Lung Diseases; Respiratory Tract Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Delayed; Hypersensitivity; Immune System Diseases; Neoplasms by Histologic Type; Neoplasms; Immunoproliferative Disorders

Intervention Hierarchy (Ancestors)

Biopsy; Cytodiagnosis; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Specimen Handling; Diagnostic Techniques, Surgical; Surgical Procedures, Operative; Lymph Node Excision; Investigative Techniques

Study Officials

• ahmed mahmoud fawzy, professor

  Alexandria University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: lecturer

Study Record Dates

• First Submitted: January 7, 2026
• First Posted: January 15, 2026
• Study Start: August 1, 2025
• Primary Completion: December 30, 2025
• Study Completion: January 1, 2026
• Last Updated: January 15, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)