NCT07343011

Brief Summary

This prospective single-arm interventional study evaluates the recurrence rate and functional outcomes following conjunctival transpositional pterygium surgery without bare sclera formation. The technique involves mobilization and transposition of the pterygium tissue while preserving Tenon's layer and avoiding adjunctive therapies.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
70

participants targeted

Target at P50-P75 for not_applicable

Timeline
8mo left

Started May 2025

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress60%
May 2025Jan 2027

Study Start

First participant enrolled

May 21, 2025

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

January 6, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 15, 2026

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Expected
Last Updated

January 15, 2026

Status Verified

January 1, 2026

Enrollment Period

12 months

First QC Date

January 6, 2026

Last Update Submit

January 6, 2026

Conditions

Pterygium of the Conjunctiva and Cornea

Outcome Measures

Primary Outcomes (1)

  • Pterygium Recurrence

    Recurrence is defined as fibrovascular regrowth toward the cornea or surgical failure.

    12 months

Secondary Outcomes (2)

  • Visual Acuity

    12 months

  • Refractive Astigmatism

    12 months

Study Arms (1)

Pterygium patients

EXPERIMENTAL
Procedure: Conjunctival Transpositional Pterygium Surgery

Interventions

Conjunctival Transpositional Pterygium SurgeryPROCEDURE

A conjunctival incision was created at the upper and lower limbus to allow adequate tissue mobilization. The pterygium tissue is dissected off the corneal surface without complete excision or creation of a bare sclera defect. The fibrovascular tissue is mobilized and transposed inferiorly within the subconjunctival plane and secured with absorbable sutures. Tenon's tissue is preserved, and no adjunctive therapy is used.

Pterygium patients

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Adults aged 18 years or older
  • Primary pterygium involving the cornea
  • Ability to provide informed consent

You may not qualify if:

  • Recurrent pterygium
  • Previous ocular surface surgery
  • Active ocular infection or inflammation
  • Severe ocular surface disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Alzahra Eye Hospital, Zahedan University of Medical Sciences

Zahedan, Sistan and Balochistan, Iran

RECRUITING

MeSH Terms

Conditions

Corneal Diseases

Condition Hierarchy (Ancestors)

Eye Diseases

Central Study Contacts

Mohammed Arish, MD, FRCS

CONTACT

09151419155mohammad.erish@zaums.ac.ir

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate professor of ophthalmology

Study Record Dates

First Submitted

January 6, 2026

First Posted

January 15, 2026

Study Start

May 21, 2025

Primary Completion

May 1, 2026

Study Completion (Estimated)

January 1, 2027

Last Updated

January 15, 2026

Record last verified: 2026-01

Locations

IR(1)