Telemedicine for Evaluating Dry Eye Disease (DED) Using a Mobile Phone-Attached Portable Automatic Ocular Surface Imaging Device (PAOSID): A Patient-Operated Diagnostic and Continuous Ocular Surface Monitoring (COSM) System

NCT07341724 | Not Yet Recruiting

• 1 other identifier: 2025-0263
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Dry eye disease (DED) is a common eye condition that is becoming more widespread. Detecting it early, keeping track of its progression, and following up regularly can help protect vision and prevent serious complications. However, due to a shortage of ophthalmologists, limited access to eye care services, and disparities in care quality, many patients receive infrequent or insufficient clinical consultations. To address these needs, a portable automatic ocular surface imaging device (PAOSID) that attaches to a mobile phone has been developed. This device uses three types of light including white, infrared, and cobalt blue light to capture clear images and videos of the eye's surface. It also has a smart system that automatically takes high-quality images, allowing patients to use it at home independently. This device may help detect early signs of DED and monitor eye health more easily.

Conditions

Dry Eye; Dry Eye Disease (DED)

Keywords

PAOSID; Dr EYE

Outcome Measures

Primary Outcomes (1)

• The primary objective is to study the diagnostic accuracy of remote Dry Eye Disease (DED) diagnosis using a portable automatic ocular surface imaging device (PAOSID), as compared with standard clinical DED diagnosis.

  From enrollment to end of visit 1, estimated 1 hour (One Time Visit)

Secondary Outcomes (1)

• The secondary objectives: diagnostic consistency of remote Dry Eye Disease (DED) diagnosis using a portable automatic ocular surface imaging device (PAOSID), as compared with standard clinical DED diagnosis.

  From enrollment to end of visit 1, estimated 1 hour (One Time Visit)

Study Arms (2)

Patient diagnose with Dry Eye Disease

OTHER

Diagnostic Test: Dr Eye

Healthy subject

OTHER

Diagnostic Test: Dr Eye

Interventions

Dr Eye DIAGNOSTIC_TEST

Portable automatic ocular surface imaging device (PAOSID) that attaches to a mobile phone has been developed. This device uses three types of light including white, infrared, and cobalt blue light to capture clear images and videos of the eye's surface. It also has a smart system that automatically takes high-quality images, allowing patients to use it at home independently. This device may help detect early signs of DED and monitor eye health more easily.

Healthy subject; Patient diagnose with Dry Eye Disease

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants diagnosed as DED by experienced ophthalmologists, based on the TFOS DEWS II (The Tear Film and Ocular Surface Society Dry Eye Workshop II) guidelines,(19) as well as healthy individuals with no ocular conditions who voluntarily agreed to participate in the study;
• Participants, or their companions or caregivers, who are willing and able to use the study smartphone to capture relevant eye images and videos;
• Aged 21 years or older;
• Provide informed consent.

You may not qualify if:

• Participants with ocular surface disorders other than DED that may affect the appearance of the ocular surface (e.g., pterygium, keratitis, corneal scarring) or with any organic pathologies impacting vision (e.g., cataracts, glaucoma, retinal diseases).
• Patients currently wearing scleral lenses or bandage contact lenses.
• Significant changes in the ocular images since diagnosis due to factors such as postdiagnostic treatment;
• Unable to cooperate with the PAOSID, such as due to a serious mental illness or brain damage causing loss of limb control;
• Eyes with previous or active corneal diseases such as infectious keratitis, corneal opacity or dystrophy;
• Eyes with active inflammation or infection.

Sponsors & Collaborators

• Singapore National Eye Centre: lead
• The Eye Hospital of Wenzhou Medical University: collaborator

MeSH Terms

Conditions

Dry Eye Syndromes

Condition Hierarchy (Ancestors)

Lacrimal Apparatus Diseases; Eye Diseases

Study Officials

• Louis Tong, PhD

  Singapore Eye Research Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Louis Tong, PhD

CONTACT

65767200; louis.tong.h.t@singhealth.com.sg

Sharon Yeo, BSc

CONTACT

65767200; sharon.yeo.w.j@seri.com.sg

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinician-Scientist, Senior Consultant

Study Record Dates

• First Submitted: December 21, 2025
• First Posted: January 14, 2026
• Study Start: January 9, 2026
• Primary Completion (Estimated): July 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: January 14, 2026

Record last verified: 2025-12