Does Vitamin C Increase the Body Heat Generated By The Nervous System?

NCT07341308 | Recruiting

• 1 other identifier: 6115
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The goals of this clinical trial are to determine whether or not vitamin C is able to: (1) increase the body heat generated by the sympathetic nervous system; and, (2) increase circulating vitamin D concentration during sympathetic nervous system stimulation in adult humans aged 18-40 years who meet the criteria for overweight based on body mass index. The main question it aims to answer are:

• undergo measures of body temperature
• have blood sampled on two separate occasions: once during stimulation of beta adrenergic receptors, and once during stimulation of beta-adrenergic receptors while also been given vitamin C.

Conditions

Metabolism Changes; Vitamin D

Keywords

isoproterenol; vitamin c; vitamin d; body temperature

Outcome Measures

Primary Outcomes (2)

• Body Temperature

  Body temperature will be measured using an oral thermometer

  Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.

• Vitamin D

  Circulating vitamin D concentration

  Prior to and immediately after a dose of isoproterenol. This corresponds to 0 minutes (baseline) and immediately after each dose of isoproterenol at minutes 30, 60 and 90.

Study Arms (2)

Response to beta-adrenergic stimulation without vitamin C

NO INTERVENTION

Isoproterenol will be infused with saline only

Adding vitamin C to beta-adrenergic receptor stilmulation

EXPERIMENTAL

Isoproterenol will be infused with vitamin C

Other: Vitamin C

Interventions

Vitamin C OTHER

Vitamin C will be co-infused with isoproterenol

Adding vitamin C to beta-adrenergic receptor stilmulation

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-40 years (inclusive)
• Body mass index greater than or equal to 25 kg/m2 and less than 30 kg/m2
• Weight stable (no change in body mass greater than 5 Lbs. within the previous 6 months.
• Willing to abstain from caffeine and alcohol for 24-hours prior to two different study visits
• Competency in English as assessed by comprehension of the Informed Consent. This is study involves invasive procedures and infusion of a systemic vasoactive agent (isoproterenol); for safety reasons, the ability for clear and rapid communication will be necessary between the research participants and the investigators.

You may not qualify if:

• History of autonomic, cardio-pulmonary, and/or metabolic disease (including heart failure, hypertension, arrhythmia, vascular disease, and/or diabetes)
• Pregnancy or breast feeding
• Habitual use of tobacco/nicotine products or recreational drugs (2 or more uses within the previous month)
• History of a "sulfite allergy" as it is a relative contraindication to isoproteronol use.
• Has ingested vitamin supplements and/or antioxidant supplements during the previous 4-weeks (e.g. Vitamin C, Vitamin E, Multi-vitamins, etc.)

Sponsors & Collaborators

• Colorado State University: lead

Study Sites (1)

Colorado State University

Fort Collins, Colorado, 80523, United States

RECRUITING

MeSH Terms

Interventions

Ascorbic Acid

Intervention Hierarchy (Ancestors)

Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates

Study Officials

• Christopher Bell, PhD

  Colorado State University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Christopher Bell, PhD

CONTACT

9704917522; christopher.bell@colostate.edu

Taylor Ewell, M.S.

CONTACT

9704913495; Taylor.Ewell@colostate.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: January 14, 2026
• Study Start: March 17, 2025
• Primary Completion (Estimated): June 8, 2026
• Study Completion (Estimated): December 8, 2026
• Last Updated: January 14, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)