Evaluation of a Neuropsychological Tool to Assess Temporal Processing Abilities in Alzheimer's Disease

NCT07341009 | Recruiting DMC

• 1 other identifier: 25-0136
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Perceiving and representing the passage of time allows us to temporally organize perceptions and memories for the coordination of actions, planning, and the mobilization of cognitive processes toward a goal. This innovative project aims to clarify the profile of time impairment associated with normal aging and the progression of age-related pathologies. This project proposes to develop a new neuropsychological tool for quantifying and preventing changes in the relationship to time associated with Alzheimer's disease. Four aspects of time are distinguished, which are measured separately and distributed along a continuum between perception and memory: (a) perception of simultaneity and order; (b) processing of durations; (c) subjective sense of the passage of time; and (d) mental time travel. Crucially, many neurological and psychiatric disorders are associated with impairment in one or more aspects of time. However, time remains largely unexplored in clinical practice. Patients with Alzheimer's disease will complete the CHRONOS battery. This battery allows for a rapid assessment (approximately ten minutes) of the four aspects of time. This new battery will enable the identification of behavioral markers aimed at improving prognosis and prevention regarding individual cognitive trajectories of aging. The relationship to time is closely linked to each person's personal experience. This project will help to put into words difficulties that are not always expressed in terms of time. Thus, considering these pathologies from the perspective of time aims to better understand and prevent their difficulties and to guide the identification of new markers and new avenues for remediation.

Conditions

Alzheimer's Disease (AD); Time Perception

Keywords

temporal cognition; dementia; cognition; neuropsychology

Outcome Measures

Primary Outcomes (1)

• Behavioral difference at the battery assessing temporal processing (CHRONOS (Cognitive Health Ratings Of Neuropsychological Skills for temporal perception) Score /30 + subscores)

  From enrollment to the end of the neuropsychological assessment (three hours)

Study Arms (1)

Alzheimer's patients

Behavioral: Chronos battery

Interventions

Chronos battery BEHAVIORAL

Patients will perform the battery during a neuropsychological assessment

Alzheimer's patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Alzheimer's disease

You may qualify if:

• No objection from the participant or their legal representative, if applicable, prior to or during the assessment
• Deficit in at least two cognitive functions, including episodic memory.

You may not qualify if:

• History of head trauma with loss of consciousness lasting more than 1 hour
• Presence of clinically significant major psychiatric disorders (according to DSM-IV-TR criteria)
• Use of medications likely to alter cognitive and/or brain function (decision by the principal investigator)

Sponsors & Collaborators

• University Hospital, Caen: lead

Study Sites (1)

Caen Hospital, neurology Unit

Caen, 14000, France

RECRUITING

MeSH Terms

Conditions

Alzheimer Disease; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Marianne Hebert

CONTACT

+33231065728; hebert-maria@chu-caen.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: January 14, 2026
• Study Start: December 30, 2025
• Primary Completion (Estimated): November 1, 2027
• Study Completion (Estimated): November 1, 2027
• Last Updated: March 19, 2026

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)