Fertility Outcomes of Ovarian Tissue Cryopreservation

NCT07339995 | Not Yet Recruiting

• 1 other identifier: PAED-2025-067
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

With the advancement of assisted reproductive technology, more young cancer patients can consider having children. Ovaries and testes are important reproductive organs, and drugs, diseases, chemotherapy, and radiotherapy can all damage them. Reproductive preservation technology aims to protect patients whose reproductive ability has been damaged due to gonadotoxic drug therapy. Women can preserve their reproductive ability by freezing ovarian tissue cryopreservation so that they can have children in the future. Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital will be invited to participate in the study. Here, we aim to evaluate the outcomes after ovarian tissue cryopreservation.

Conditions

Neoplasms

Outcome Measures

Primary Outcomes (2)

• Surgical complications

  Surgical complications after ovarian tissue transplantation

  15 years

• Pregnancy rate

  Pregnancy rate after ovarian tissue transplantation

  15 years

Interventions

Ovarian tissue freezing and subsequent auto-transplantation after thawing OTHER

Removal of the ovarian tissue will be retrieved via laparoscopic surgery under general anesthesia. The ovarian cortical tissue obtained will be transferred on ice to the laboratory for cryopreservation. After medical treatment, if the patient would like to start a family but has experienced premature ovarian failure, she will have ovarian tissue auto-transplantation after thawing.

Eligibility Criteria

• Age: 0 Years - 18 Years
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients who have undergone or will undergo ovarian tissue cryopreservation in the Hong Kong Children's Hospital will be invited to join this study.

You may qualify if:

• Patients aged from 0-18 years old and diagnosed with cancer
• Patients who have undergone or will undergo ovarian tissue cryopreservation in Hong Kong Children's Hospital
• For patients under 18 years old, parents/legal guardians will be asked to further sign the consent for them.

You may not qualify if:

• Patients unable to provide consent/assent (i.e. significant psychiatric problems/cognitive delay)
• Male patients

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

MeSH Terms

Conditions

Neoplasms

Study Officials

• Pui Wah Jacqueline Chung

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Elaine Ng

CONTACT

35052745; elaineng@cuhk.edu.hk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: January 6, 2026
• First Posted: January 14, 2026
• Study Start: January 15, 2026
• Primary Completion (Estimated): January 14, 2031
• Study Completion (Estimated): January 14, 2032
• Last Updated: January 14, 2026

Record last verified: 2026-01