Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years

NCT07339865 | Enrolling By Invitation DMC

• 1 other identifier: ONZ-2024-0541
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

With this study, we would like to interview 16-25-year-olds who have experienced urinary problems since childhood and who are still experiencing symptoms in young adulthood. The transition from childhood, through puberty, to young adulthood is a time period marked by many psychological ans physiological changes, during which it can be difficult to properly monitor certain symptoms. With this study, we aim to gather opinions and experiences of adolescents and young adults in order to improve urological care for other patients in the future.

Conditions

Transition Care; Enuresis Nocturnal; Adverse Childhood Experiences; Genitourinary Issues; Constipation; Sleep Quality; Quality of Life; Lower Urinary Tract Symptoms (LUTS)

Keywords

Transition Care; Adolescents; Lower urinary tract symptoms (LUTS); Mixed-method research; Pediatric urology; Functional Urology; Interviews; Urological Time-line; Questionnaires

Outcome Measures

Primary Outcomes (1)

• Perceptions, Attitudes, and Experiences Regarding Transition from Pediatric to Adult Urological Care

  Assessment of adolescents' perceptions, attitudes, and experiences related to the transition from pediatric to adult urological care, as measured using a semi-structured in-depth interview after or during completion of the transition process, depending of the age of the included participant.

  Baseline (single assessment)

Secondary Outcomes (7)

• Persisting LUTS in adolescence

  Baseline (single assessment)

• Constipation complaints

  Baseline (single assessment)

• Sleep quality

  Baseline (single assessment)

• Quality of Life reporting

  Baseline (single assessment)

• Quality of Life - LUTS related

  Baseline (single assessment)

Study Arms (1)

Adolescents and young adults (AYA)

Adolescents and young adults (AYA) with persisting childhood LUTS, none related to a congenital or neurological disorder.

Other: Semi-structured in-depth interviews with standardized validated questionnaires; Other: Completion of a urological time-line

Interventions

Completion of a urological time-line OTHER

Participants complete a blank timeline representing their urological care pathway from birth to the moment of the in-depth interview.

Adolescents and young adults (AYA)

Semi-structured in-depth interviews with standardized validated questionnaires OTHER

Interviews utilize a semi-structured format, with one researcher conducting all interviews to ensure consistency. A piloted, multidisciplinary-approved interview guide is used to ask open-ended questions exploring adolescent transition experiences.

Adolescents and young adults (AYA)

Eligibility Criteria

• Age: 16 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years (STREAMWAY) aims to map perceptions, attitudes and experiences of adolescents who have undergone the transfer from paediatric to adult urological care. Participants should have received follow-up care for childhood LUTS from a general practitioner, urologist, paediatric urologist, or paediatric nephrologist. At the initial study visit, before enrolment, AYA patients with LUTS undergo a complete diagnostic work-up as part of standard care to determine the presence of LUTS at the time of consultation.

You may qualify if:

• LUTS (according to ICCS definition) present during childhood
• Participants receiving follow-up care for LUTS from a general practitioner, urologist, paediatric urologist, or paediatric nephrologist.
• Individuals aged 16-25 years who have recently transitioned to adult care or are currently undergoing the transition process.

You may not qualify if:

• Patients not comfortable conducting interviews and completing questionnaires in Dutch
• Participants with neurological conditions or congenital anatomical anomalies that may cause LUTS, as these individuals are already followed in established transition pathways and cannot be compared to the target population
• Individuals with cognitive impairments that impair their capacity to independently participate in interviews or complete questionnaires.

Sponsors & Collaborators

• University Ghent: collaborator
• University Hospital, Ghent: lead

Study Sites (1)

Ghent University Hospital

Ghent, East-Flanders, 9000, Belgium

Location

Related Publications (2)

• Karamaria S, Mauel R, Van den Ende M, Oosterlinck A, Verheye A, De Bruyne E, Degrauewe E, Dhondt K, Dossche L, Raes A, Renson C, Samijn B, Spinoit AF, Everaert K, Walle JV. Transition in enuresis patients: Identifying the gaps and opportunities for the future. Neurourol Urodyn. 2024 Jun;43(5):1118-1126. doi: 10.1002/nau.25460. Epub 2024 Apr 8.

  PMID: 38587243 BACKGROUND

• Van den Ende M, Joinson C, Sinha S, Verbakel I, Ochoa DC, Lazar J, Baird A, Selai C, Van Huele A, Bou Kheir G, Spinoit AF, Abrams P, Everaert K, Herve F. Navigating the waters of LUTS from childhood to puberty - NOPIA meeting (ICI-RS 2024). J Pediatr Urol. 2025 Dec;21(6):1477-1485. doi: 10.1016/j.jpurol.2025.07.011. Epub 2025 Aug 18.

  PMID: 40829984 BACKGROUND

Related Links

• ICCS Online Webinar - Lifelong LUTS and Adolescent Enuresis
• Article on topic of transition in urology (Dutch) - Promotion of initiation study

MeSH Terms

Conditions

Lower Urinary Tract Symptoms; Nocturnal Enuresis; Constipation; Sleep Initiation and Maintenance Disorders

Condition Hierarchy (Ancestors)

Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Enuresis; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Behavioral Symptoms; Behavior; Elimination Disorders; Mental Disorders; Signs and Symptoms, Digestive; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 14, 2026
• Study Start: February 28, 2025
• Primary Completion (Estimated): July 31, 2026
• Study Completion (Estimated): December 31, 2029
• Last Updated: January 14, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)