NCT07339800

Brief Summary

Invasive pulmonary fungal infections caused by Mucorales are rare but severe and rapidly progressive, affecting immunocompromised patients. The role of chest imaging in their diagnosis is well established in the 2020 EORTC/MSGERC criteria, and its use is almost systematic. However, the progression of lung parenchymal involvement and any potential prognostic radiological patterns in the follow-up of these infections are less well understood. This research aims to identify imaging characteristics predictive of favorable or unfavorable outcomes in infected patients, in order to better tailor follow-up and therapeutic options.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for all trials

Timeline
4mo left

Started Sep 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress63%
Sep 2025Sep 2026

Study Start

First participant enrolled

September 18, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

January 5, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

January 14, 2026

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2026

Expected
18 days until next milestone

Study Completion

Last participant's last visit for all outcomes

September 19, 2026

Last Updated

January 14, 2026

Status Verified

January 1, 2026

Enrollment Period

12 months

First QC Date

January 5, 2026

Last Update Submit

January 5, 2026

Conditions

Pulmonary Mucormycosis

Keywords

Pulmonary MucormycosisFungal infections

Outcome Measures

Primary Outcomes (1)

  • Death rate in patients with probable or proven invasive Mucorales infection

    Death rate at day 15 in patients with probable or proven invasive Mucorales infection

    Day 15 after infection

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients with a diagnosis of probable or proven invasive pulmonary infection with Mucorales according to the 2020 EORTC/MSGERC criteria

You may qualify if:

  • Patients aged 18 years or older
  • Treated at Strasbourg University Hospital between January 1, 2009, and June 3, 2025
  • With a diagnosis of probable or proven invasive pulmonary infection with Mucorales according to the 2020 EORTC/MSGERC criteria
  • Having undergone at least one CT scan including the thoracic region

You may not qualify if:

  • No CT scan including the thoracic region
  • No diagnosis of probable or proven invasive pulmonary infection with Mucorales (EORTC/MSGERC 2020 criteria)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Service des Maladies Infectieuses et Tropicales - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Mycoses

Condition Hierarchy (Ancestors)

Bacterial Infections and MycosesInfections

Central Study Contacts

baptiste Hoellinger, MD

CONTACT

33 3 69 55 05 45baptiste.hoellinger@chru-strasbourg.fr

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 5, 2026

First Posted

January 14, 2026

Study Start

September 18, 2025

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

September 19, 2026

Last Updated

January 14, 2026

Record last verified: 2026-01

Locations

FR(1)