The Optimising Isolation, Quarantine and Distancing Study for COVID-19

NCT07337382 | Active Not Recruiting DMC

• 1 other identifier: 202006
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 2

Brief Summary

The Australian government swift interventions and actions early to the COVID 19 epidemic included enforced quarantine, isolation, varying degrees of social and physical distancing measures, travel restrictions, community level testing and enhanced contact tracing models which effected the trajectory of the epidemic impact. While the search for effective therapeutics and vaccines continues, it is important to understand how to effectively implement and optimise the current public health interventions available; application of traditional contact tracing , contributions of new contact tracing mobile phone applications, community level testing and use of specific fit for purpose diagnostic tests; to screen, detect and provide evidence of infection clearance. While the suppression measures have been effective on disease transmission rates, it has had economic, social and non COVID-19 health costs impacts. As community restrictions change it will be important to monitor and evaluate the effectiveness of these key interventions. This is a longitudinal study that will follow the experience and behaviors of 2 key risk populations impacted by COVID-19 transmission containment measures.

Conditions

COVID19

Outcome Measures

Primary Outcomes (5)

• Change from response in baseline questionnaires to Adherence (non-adherence) with COVID19 transmission containment measures

  Participants will complete behavioural questionnaires and diaries as binary daily measure of outcomes of compliance/non-adherence for each individual, determined by their ability to adhere to government regulations

  18 months

• Change from response in baseline questionnaires depicting what are the unintended health, social and economic consequences of the government response to control COVID19 transmission

  Participants will complete behavioural questionnaires and diaries. e.g. Anxiety (using GAD scale: https://patient.info/doctor/generalised-anxiety-disorder-assessment-gad-7).

  18 months

• What are the social contacts and mixing patterns of COVID-19 cases

  The behavioural questionnaire participants will be ask to complete include nominating the number of social network contacts per day.

  18 months

• What are the types of social contacts and mixing patterns of COVID-19 cases

  The questionnaire participants will be ask to complete will include nominating the relationship with their contacts per day(i.e. partner, child, friend), and individuals COVID test status, providing detailed specifics of the projects social network data.

  18 months

• Measure of the efficacy of government interventions,

  Participants responses to behavioural questionnaires and focus group discussions will be used as binary measurers; including but not limited to the number/proportion of participants who receive a score indicating accurate knowledge of government recommendations, receive a score of using COVID-19 prevention measures as recommended by the government.

  18 months

Secondary Outcomes (3)

• Collect data of positive COVID19 cases reported in study participant questionnaires.

  18 months

• Assess the effectiveness of government interventions to reduce COVID-19 transmission from questionnaire responses from cohort participants

  18 months

• To investigate new and alternative tests to diagnose COVID-19.

  18 months

Study Arms (2)

Observational Group 1

Group 1/Seed set 1 - recently diagnosed 'COVID-19 cases' (Group 1) and their social network with up to 2 waves of /Key people, will be followed up for 1 month initially with specific monitoring tools before they will transition into ongoing follow up and monitoring as recruitment group 2

Observational Group 2

Group 2/Seed set 2 - people from the general community that are not currently infected with COVID19 'Group 2' that are practicing physical distancing and represent specific key risk groups, and their social network with up to 2 waves of Key people

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Participants adults living in Victoria

You may qualify if:

• Community participants -

You may not qualify if:

• Unable to provide consent -

Sponsors & Collaborators

• The Peter Doherty Institute for Infection and Immunity: collaborator
• University of Melbourne: collaborator
• Swinburne University of Technology: collaborator
• La Trobe University: collaborator
• Monash University: collaborator
• SNA Toolbox: collaborator
• Centre for Culture, Ethnicity & Health: collaborator
• Macquarie Group Foundation: collaborator
• Victorian State Government: collaborator
• Macfarlane Burnet Institute for Medical Research and Public Health Ltd: lead

Study Sites (2)

The Macfarlane Burnet Institute for Medical Research and Public Health

Melbourne, Victoria, 3004, Australia

Location

The Peter Doherty Institute for infection and immunity

Melbourne, Victoria, 3050, Australia

Location

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 5, 2020
• First Posted: January 13, 2026
• Study Start: September 30, 2020
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: January 13, 2026

Record last verified: 2025-10

Locations

AU (2)