Istmin Levels in Laparoscopik Sleeve Gastrectomy

NCT07335549 | Completed

• 1 other identifier: EFSCH1
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Obesity is a multifactorial disease which has become a public health problem with increasing frequency, especially in recent years. Obesity causes many health problems with its negative effects on organs, systems, and psychosocial status. It is a serious risk factor for many diseases and also causes a significant increase in morbidity and mortality in these diseases. Although dietary treatments and medical treatment options are frequently used, surgical options are still the most effective treatment. Bariatric and metabolic surgical techniques are frequently applied, especially in patients with advanced obesity and obesity-related comorbidities. The most commonly applied bariatric metabolic surgical techniques, as in our clinic, are laparoscopic sleeve gastrectomy (LSG) and Roux-en-y gastric bypass procedures. The role of adipokines, secreted from adipose tissue and thought to play a role in the development of obesity, is quite important in the obesity mechanism, as they are effective not only in energy processes but also in metabolic processes. These adipokines secreted by adipose tissue play an active role in many mechanisms in the body, including vasoactivity, oxidative processes, immunity, lipid and glucose metabolism. Adipokines function actively in many target organs such as the pancreas, liver, and brain. Isthmin, a relatively new adipokine expressed from brown and white adipocytes, also affects many systems like other adipokines. Studies have shown that Isthmin plays an active role in glucose and lipid metabolism, and it has been reported to play a role in many metabolic processes, from insulin resistance to hepatic steatosis. The aim of this study is to investigate whether isthmin levels change before and after surgery in patients undergoing LSG for severe obesity, given that isthmin is thought to be associated with obesity and insulin resistance, particularly by affecting the appetite center in metabolism.

Conditions

Obesity & Overweight; Sleeve Gastrectomy; Adipokines

Keywords

Severe Obesity; Laparoscopic Sleeve Gastrectomy; Isthmin; Adipokines

Outcome Measures

Primary Outcomes (1)

• Serum Isthmin Levels' change

  Serum Isthmin Levels' change

  Preoperative and postoperative third month

Study Arms (1)

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Diagnostic Test: Preoperative Serum Isthmin Levels; Diagnostic Test: Postoperative Third Month's Serum Isthmin Levels; Other: Preoperative BMI; Other: Postoperative BMI

Interventions

Preoperative Serum Isthmin Levels DIAGNOSTIC_TEST

Preoperative Serum Isthmin Levels

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Postoperative Third Month's Serum Isthmin Levels DIAGNOSTIC_TEST

Postoperative Third Month's Serum Isthmin Levels

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Preoperative BMI OTHER

Preoperative the height and the weight of the patient will record. After that BMI will be calculated as formula "The Body Weight (kg)/(The Height (meters)x The Height (meters))

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Postoperative BMI OTHER

Postoperative third month's the height and the weight of the patient will record. After that BMI will be calculated as formula "The Body Weight (kg)/(The Height (meters)x The Height (meters))

Laparoscopic Sleeve Gastrectomy Patients for Severe Obesity

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

BMI \> 40 kg/m2 without comorbidity who are planned for Laparoscopic Sleeve Gastrectomy

You may qualify if:

• Being over 18 years of age
• Being diagnosed with severe obesity
• Patients who do not wish to participate in the study

You may not qualify if:

• Patients under 18 years of age
• Overweight patients with a Body Mass Index \<40 kg/m2 and no comorbidities
• Patients with rheumatological diseases (rheumatoid arthritis, SLE, etc.)
• Patients with chronic kidney and liver failure
• Patients diagnosed with Diabetes Mellitus
• Patients with malignancy
• Patients who do not wish to participate in the study

Sponsors & Collaborators

• Saglik Bilimleri Universitesi: lead

Study Sites (1)

Elazig Fethi Sekin City Hospital

Elâzığ, 23100, Turkey (Türkiye)

Location

Related Publications (7)

• Lopez-Yus M, Casamayor C, Soriano-Godes JJ, Borlan S, Gonzalez-Irazabal Y, Garcia-Sobreviela MP, Garcia-Rodriguez B, Del Moral-Bergos R, Calmarza P, Artigas JM, Lorente-Cebrian S, Bernal-Monterde V, Sanz-Paris A, Arbones-Mainar JM. Isthmin-1 (ISM1), a novel adipokine that reflects abdominal adipose tissue distribution in individuals with obesity. Cardiovasc Diabetol. 2023 Dec 8;22(1):335. doi: 10.1186/s12933-023-02075-0.

  PMID: 38066623 BACKGROUND

• Dunmore SJ. Of fat mice and men: the rise of the adipokines. J Endocrinol. 2013 Jan 2;216(1):E1-2. doi: 10.1530/JOE-12-0513. Print 2013 Jan. No abstract available.

  PMID: 23160965 BACKGROUND

• Fasshauer M, Bluher M. Adipokines in health and disease. Trends Pharmacol Sci. 2015 Jul;36(7):461-70. doi: 10.1016/j.tips.2015.04.014. Epub 2015 May 25.

  PMID: 26022934 BACKGROUND

• Peri K, Eisenberg M. Review on obesity management: bariatric surgery. BMJ Public Health. 2024 Nov 27;2(2):e000245. doi: 10.1136/bmjph-2023-000245. eCollection 2024 Dec.

  PMID: 41201062 BACKGROUND

• Kirkil C, Aygen E, Korkmaz MF, Bozan MB. QUALITY OF LIFE AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY USING BAROS SYSTEM. Arq Bras Cir Dig. 2018 Aug 16;31(3):e1385. doi: 10.1590/0102-672020180001e1385.

  PMID: 30133677 BACKGROUND

• GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1223-1249. doi: 10.1016/S0140-6736(20)30752-2.

  PMID: 33069327 BACKGROUND

• Jiang Z, Zhao M, Voilquin L, Jung Y, Aikio MA, Sahai T, Dou FY, Roche AM, Carcamo-Orive I, Knowles JW, Wabitsch M, Appel EA, Maikawa CL, Camporez JP, Shulman GI, Tsai L, Rosen ED, Gardner CD, Spiegelman BM, Svensson KJ. Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis. Cell Metab. 2021 Sep 7;33(9):1836-1852.e11. doi: 10.1016/j.cmet.2021.07.010. Epub 2021 Aug 3.

  PMID: 34348115 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Preoperative rotuine blood samples and postopoperastive third month routine control's blood samples

MeSH Terms

Conditions

Obesity; Overweight; Obesity, Morbid

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Mehmet B Bozan, Professor

  Turkish Health Sciences University Elazig City Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Proefessor, Associate MD

Study Record Dates

• First Submitted: January 2, 2026
• First Posted: January 13, 2026
• Study Start: July 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: January 1, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)