Cognition Assessment and REhabilitation in Virtual Reality for Patients With Cancer

NCT07335393 | Not Yet Recruiting DMC

• 2 other identifiers: 2025-0993NUSSUG2025
• Study Type: interventional
• Target: 64
• Locations: 0 countries
• Sites: N/A

Brief Summary

1. 1.To assess the cognitive function of patients with cancer by leveraging a validated virtual reality (VR)-based cognitive assessment tool.
2. 2.To evaluate the efficacy of VR-based cognitive rehabilitation therapy (VR-CRT) compared to a control group in improving cognitive functions in cancer patients.

Conditions

Patients With Cancer

Keywords

Cancer; Virtual Reality; Cognitive Rehabilitation Therapy; Cancer-related cognitive impairment; Quality of Life

Outcome Measures

Primary Outcomes (2)

• VR Cognition Assessment Tool

  Effects of VR-based cognitive rehabilitation therapy (VR-CRT) compared to standard care only (Control) on cognitive function measured objectively using VR Cognition Assessment Tool. Mean change in VR Cognition Assessment Tool from Visit 1 (Recruitment) to Visit 2 (Last day of intervention), and Visit 3 (Final follow-up, Day 90 post-intervention with allowance of + 7 days).

  From enrollment to Day 90 post-intervention (with allowance of + 7 days).

• Subjective cognitive function by FACT-Cog

  Effects of VR-based cognitive rehabilitation therapy (VR-CRT) compared to standard care only (Control) on subjective cognitive function measured using Functional Assessment of Cancer Therapy - Cognitive Function (FACT-Cog). Mean change in FACT-Cog from Visit 1 (Recruitment) to Visit 2 (Last day of intervention), and Visit 3 (Final follow-up, Day 90 post-intervention with allowance of + 7 days).

  From enrollment to Day 90 post-intervention (with allowance of + 7 days).

Secondary Outcomes (4)

• EQ5D-5L

  From enrollment to Day 90 post intervention (with allowance of + 7 days).

• Virtual Reality Simulation Sickness Questionnaire (VRSQ)

  From enrollment to Day 90 post-intervention (with allowance of + 7 days).

• User-friendliness and engagement

  From enrollment to Day 90 post-intervention (with allowance of + 7 days).

• Treatment satisfaction by VAS

  From enrollment to Day 90 post-intervention (with allowance of + 7 days)

Study Arms (2)

VR-based cognitive rehabilitation therapy (VR-CRT)

EXPERIMENTAL

Intervention Arm

Behavioral: VR-based cognitive rehabilitation therapy (VR-CRT)

Standard Care only

NO INTERVENTION

Control arm

Interventions

VR-based cognitive rehabilitation therapy (VR-CRT) BEHAVIORAL

12 VR-CRT sessions over 4 weeks, with sessions occurring 3 times per week, targeting attention, memory, and executive function

VR-based cognitive rehabilitation therapy (VR-CRT)

Eligibility Criteria

• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• (1) Cancer (both Solid and haematological) patients with documented cognitive impairments. (2) No history of neurological disorders. (3) Ability to use VR technology.

You may not qualify if:

• Severe visual or auditory impairments, motion sickness, or conditions interfering with VR use.

Sponsors & Collaborators

• JING MINGXUE: lead
• National University of Singapore: collaborator

Related Publications (2)

• Zeng Y, Guan Q, Su Y, Huang Q, Zhao J, Wu M, Guo Q, Lyu Q, Zhuang Y, Cheng AS. A self-administered immersive virtual reality tool for assessing cognitive impairment in patients with cancer. Asia Pac J Oncol Nurs. 2023 Feb 28;10(3):100205. doi: 10.1016/j.apjon.2023.100205. eCollection 2023 Mar.

  PMID: 37012969 RESULT

• Zeng Y, Zeng L, Cheng ASK, Wei X, Wang B, Jiang J, Zhou J. The use of immersive virtual reality for cancer-related cognitive impairment assessment and rehabilitation: A clinical feasibility study. Asia Pac J Oncol Nurs. 2022 May 17;9(12):100079. doi: 10.1016/j.apjon.2022.100079. eCollection 2022 Dec.

  PMID: 36276883 RESULT

MeSH Terms

Conditions

Neoplasms

Study Officials

• Yingchun Zeng

  National University of Singapore

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Leonard Yeo

CONTACT

+65 8446 0373; chloezengyc@hotmail.co.uk

Yu Yang Soon

CONTACT

+65 81092059; chloezengyc@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Dr

Model Details: 1. The intervention arm will receive 12 VR-CRT sessions over 4 weeks, with sessions occurring 3 times per week, targeting attention, memory, and executive function. 2. The control arm will receive standard care only.

Study Record Dates

• First Submitted: December 30, 2025
• First Posted: January 13, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: January 13, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: ANALYTIC CODE
• Time Frame: Beginning 6 months and ending 1 years after the publication of results
• Access Criteria: Analyses that qualify for data sharing: meta-analysis Data sharing agreement needs to be signed. Applicant can email the study's Principal Investigator to submit request.