The Application of Extracellular Vesicle Detection in Gastric Juice Based on Metamaterial Sensing in the Diagnosis of Gastric Cancer and Related Diseases

NCT07332104 | Not Yet Recruiting DMC

• 2 other identifiers: BFHZS20240020No. BFHZS20240020
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

After obtaining informed consent from the patients, all the medical history and treatment records of the patients who underwent gastroscopy since the onset of the disease, as well as gastric fluid samples, including laboratory and imaging data, were collected and recorded. The medical history and treatment records and gastric fluid samples were analyzed.

Conditions

Gastric Cancer (GC); Gastric Cancer (Diagnosis)

Keywords

Gastric cancer; Extracellular vesicles

Outcome Measures

Primary Outcomes (1)

• Surface plasmon resonance(SPR) detection of extracellular vesicles in gastric juice of patients with gastric cancer has large shift and spectral changes

  baseline

Study Arms (1)

gastric cancer

Patients diagnosed with gastric cancer

Diagnostic Test: In vitro surface plasmon resonance detection

Interventions

In vitro surface plasmon resonance detection DIAGNOSTIC_TEST

Gastric juice from patients was removed for isolation of extracellular vesicles and surface plasmon resonance detection in vitro

gastric cancer

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Gastric cancer and non-cancer patients

You may qualify if:

• Patients underwent gastroscopy and treatment at the Endoscopy Center of Beijing Friendship Hospital, Capital Medical University, and received pathological biopsy.
• Previous gastroscopy suggested the possibility of lesions.
• No previous history of gastrointestinal cancer.

You may not qualify if:

• Patients could not cooperate with the examination or had contraindications to endoscopy.
• Previous history of gastrointestinal tumors, gastrointestinal surgery, physical and chemical injuries of the gastrointestinal tract.
• Severe bile reflux.
• Take simethicone and other defoaming agents before examination.
• Patients with serious diseases of heart, lung, kidney, brain, blood and other important organs.

Sponsors & Collaborators

• Beijing Friendship Hospital: lead

Biospecimen

Retention: SAMPLES WITHOUT DNA

Extracellular vesicles

MeSH Terms

Conditions

Stomach Neoplasms; Disease

Condition Hierarchy (Ancestors)

Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Stomach Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Hao-Su Zhan, Dr.

CONTACT

13565915192; 1509082764@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 14, 2025
• First Posted: January 12, 2026
• Study Start: December 15, 2025
• Primary Completion (Estimated): December 15, 2026
• Study Completion (Estimated): December 15, 2026
• Last Updated: January 12, 2026

Record last verified: 2025-12