The Prevalence of Osmophobia in Migraine and Tension-Type Headache Patients and Its Association With Migraine Symptoms Over a Period of 6 Months

NCT07329127 | Completed

• 1 other identifier: ΨΤΧ446Ψ8Ν2-4Β5
• Study Type: observational
• Target: 210
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the frequency and diagnostic value of osmophobia, which is a sensitivity to smell, in people with migraine compared to those with tension-type headache. The main question it aims to answer is: Does osmophobia reliably indicate a migraine rather than a tension-type headache? Participants diagnosed with migraine or tension-type headache at the Headache Outpatient Department of Aeginition Hospital of Athens will record their headaches and any sensitivity to smells using a headache diary and a special osmophobia calendar over a period of six months. They will also complete questionnaires about migraine burden and related health conditions.

Conditions

Migraine; Tension Headache

Keywords

migraine; osmophobia; Predictive markers; sensory hypersensitivity; diagnostic criteria

Outcome Measures

Primary Outcomes (1)

• The frequency of osmophobia in migraine and tension-type headache

  Our aim is to estimate the prevalence of osmophobia in migraine and tension type headache in order to clarify its significance as a diagnostic tool for migraine

  At baseline assessment over a six month period

Secondary Outcomes (1)

• The correlation of osmophobia with headache type and symptoms and the calculation of its sensitivity and specificity

  At baseline assessment over a six month period

Study Arms (2)

Patients with episodic or chronic migraine with or without aura

Patients with episodic or chronic tension type headache

Eligibility Criteria

• Age: 16 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients visiting the Headache Outpatient Department of Eginition Hospital of Athens

You may qualify if:

• Patients with a diagnosis of migraine or tension-type headache (ICHD-3)
• Age \>16 years
• Patients with or without medication overuse headache
• Patients with or without prophylaxis
• Patients with or without comorbidity with mood disorders
• Patients will have signed informed consent to participate in the study

You may not qualify if:

• Patients with primary or secondary anosmia
• Inability to obtain written consent

Sponsors & Collaborators

• National and Kapodistrian University of Athens: lead

Study Sites (1)

Aeginition Hospital of Athens

Athens, Greece

Location

MeSH Terms

Conditions

Migraine Disorders; Tension-Type Headache

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Neurology Resident, Neurology Department of Hôpitaux Universitaires de Genève, PHD Student

Study Record Dates

• First Submitted: December 4, 2025
• First Posted: January 9, 2026
• Study Start: January 8, 2024
• Primary Completion: December 30, 2024
• Study Completion: December 30, 2024
• Last Updated: January 9, 2026

Record last verified: 2025-12

Locations

GR (1)