CoMbination of Data From European Cohorts as Part of the European MORPHEUS Project [HORIZON-HLTH-2022-11-01] - "MC-MORPHEUS".

NCT07328152 | Recruiting

• 1 other identifier: 29BRC24.0090 - MC-MORPHEUS
• Study Type: observational
• Target: 20,000
• Locations: 1 country
• Sites: 1

Brief Summary

Combine clinical, biological and morphological data from 14 French and European cohorts into a single database.

Conditions

Venous Thromboembolism

Keywords

Venous Thromboembolism; pulmonary embolism; Anticoagulant; deep vein thrombosis

Outcome Measures

Primary Outcomes (1)

• Consistency between merged data and initial data from each cohort

  The primary outcome is the consistency between the merged dataset and the original data from each cohort, assessed by comparing key variables across sources to ensure data integrity and accuracy. Consistency will be defined as the absence of significant discrepancies in predefined variables, such as demographic characteristics, baseline measures, and primary endpoints.

  Processing of data from the fourth quarter of 2024 to the third quarter of 2025.

Secondary Outcomes (3)

• Risk of thromboembolic recurrence

  20 YEARS

• Risk of hemorrhagic complications

  20 YEARS

• Risk of death

  20 YEARS

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with MVTE who participated in one of the 14 French or European cohorts

You may qualify if:

• Cohorts led by members of the European MORPHEUS project consortium European MORPHEUS project

You may not qualify if:

• Lack of consent in cohorts

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

Chu Brest

Brest, 29609, France

RECRUITING

MeSH Terms

Conditions

Venous Thromboembolism; Pulmonary Embolism; Venous Thrombosis

Condition Hierarchy (Ancestors)

Thromboembolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Lung Diseases; Respiratory Tract Diseases; Embolism; Thrombosis

Central Study Contacts

Francis COUTURAUD

CONTACT

298347348; francis.couturaud@chu-brest.fr

Cécile TROMEUR

CONTACT

0298347348; cecile.tromeur@chu-brest.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 26, 2025
• First Posted: January 9, 2026
• Study Start: May 1, 2024
• Primary Completion: June 30, 2024
• Study Completion (Estimated): December 30, 2029
• Last Updated: January 9, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be available beginning three years and ending fifteen years following the final study report completion
• Access Criteria: Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement

Locations

FR (1)