Remission in Adults With Severe Asthma in Thailand

NCT07328035 | Recruiting

• 1 other identifier: MTU-EC-IM-0-283/68
• Study Type: observational
• Target: 230
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to determine the prevalence of remission among adults with severe asthma, as well as the factors associated with remission in Thailand. The main question the study aims to answer is: What is the prevalence of remission among adults with severe asthma in Thailand? Participants will complete questionnaires on asthma symptoms and undergo pulmonary function testing and a blood test once.

Conditions

Severe Asthma; Asthma Control Level

Keywords

asthma; remission; Thailand; severe; FeNO; blood eosinophil count

Outcome Measures

Primary Outcomes (1)

• Prevalence rate of severe asthma remission

  Prevalence rate of remission in adults with severe asthma

  The beginning of the study

Secondary Outcomes (3)

• Association of clinical characteristics with severe asthma remission

  The beginning of the study

• Association of lung function with severe asthma remission

  The beginning of the study

• Association of inflammatory biomarkers with severe asthma remission

  The beginning of the study

Study Arms (1)

Severe asthma

Asthma that requires treatment with high-dose inhaled corticosteroids plus a second controller, or requires systemic corticosteroids for ≥50% of the previous year to prevent it from becoming uncontrolled, or remains uncontrolled despite this therapy.

Other: Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires; Diagnostic Test: Spirometry; Diagnostic Test: Fractional exhaled nitric oxide (FeNO) test; Diagnostic Test: Blood eosinophil count (BEC)

Interventions

Spirometry DIAGNOSTIC_TEST

Spirometry is a tool used to assess pulmonary function.

Severe asthma

Blood eosinophil count (BEC) DIAGNOSTIC_TEST

BEC is a tool used to assess eosinophilic inflammation and asthma remission.

Severe asthma

Global Initiative for Asthma (GINA) and Asthma Control Test (ACT) questionnaires OTHER

GINA and ACT are questionnaires used to assess the level of asthma control.

Severe asthma

Fractional exhaled nitric oxide (FeNO) test DIAGNOSTIC_TEST

FeNO is a tool used to assess eosinophilic airway inflammation and asthma remission.

Severe asthma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Thai patients aged 18 years or older with severe asthma are included in the study

You may qualify if:

• severe asthma
• age 18 years or older

You may not qualify if:

• inability to perform spirometry or fractional exhaled nitric oxide (FeNO) test

Sponsors & Collaborators

• Thammasat University: lead

Study Sites (1)

Narongkorn Saiphoklang

Pathum Thani, 12120, Thailand

RECRUITING

Related Publications (7)

• McDowell PJ, McDowell R, Busby J, Eastwood MC, Patel PH, Jackson DJ, Mansur A, Patel M, Burhan H, Doe S, Chaudhuri R, Gore R, Dodd JW, Subramanian D, Brown T, Heaney LG; UK Severe Asthma Registry. Clinical remission in severe asthma with biologic therapy: an analysis from the UK Severe Asthma Registry. Eur Respir J. 2023 Dec 14;62(6):2300819. doi: 10.1183/13993003.00819-2023. Print 2023 Dec.

  PMID: 37857423 RESULT

• Tupper OD, Hakansson KEJ, Ulrik CS. Remission and Changes in Severity Over 30 Years in an Adult Asthma Cohort. J Allergy Clin Immunol Pract. 2021 Apr;9(4):1595-1603.e5. doi: 10.1016/j.jaip.2020.11.013. Epub 2020 Nov 19.

  PMID: 33220516 RESULT

• Chipps BE, Lugogo N, Carr W, Zhou W, Patel A, Carstens DD, Trudo F, Ambrose CS. On-treatment clinical remission of severe asthma with real-world longer-term biologic use. J Allergy Clin Immunol Glob. 2024 Oct 30;4(1):100365. doi: 10.1016/j.jacig.2024.100365. eCollection 2025 Feb.

  PMID: 39659738 RESULT

• Perez-de-Llano L, Scelo G, Tran TN, Le TT, Fageras M, Cosio BG, Peters M, Pfeffer PE, Al-Ahmad M, Al-Lehebi RO, Altraja A, Bergeron C, Bjermer LH, Bjerrum AS, Bulathsinhala L, Busby J, Cano Rosales DJ, Canonica GW, Carter VA, Charriot J, Christoff GC, Denton EJ, Dorscheid DR, Fernandez Sanchez MJ, Fonseca JA, Gibson PG, Goh CYY, Heaney LG, Heffler E, Hew M, Iwanaga T, Katial R, Koh MS, Kuna P, Larenas-Linnemann DES, Lehtimaki L, Mahboub B, Martin N, Matsumoto H, Menzies-Gow AN, Papadopoulos NG, Popov TA, Porsbjerg CM, Patel P, Rhee CK, Sadatsafavi M, Taille C, Torres-Duque CA, Tsai MJ, Ulrik CS, Upham JW, von Bulow A, Wang E, Wechsler ME, Price DB. Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults. Am J Respir Crit Care Med. 2024 Oct 1;210(7):869-880. doi: 10.1164/rccm.202311-2192OC.

  PMID: 38701495 RESULT

• Hansen S, Baastrup Sondergaard M, von Bulow A, Bjerrum AS, Schmid J, Rasmussen LM, Johnsen CR, Ingebrigtsen T, Hakansson KEJ, Johansson SL, Bisgaard M, Assing KD, Hilberg O, Ulrik C, Porsbjerg C. Clinical Response and Remission in Patients With Severe Asthma Treated With Biologic Therapies. Chest. 2024 Feb;165(2):253-266. doi: 10.1016/j.chest.2023.10.046. Epub 2023 Nov 3.

  PMID: 37925144 RESULT

• Holm M, Omenaas E, Gislason T, Svanes C, Jogi R, Norrman E, Janson C, Toren K; RHINE Study Group. Remission of asthma: a prospective longitudinal study from northern Europe (RHINE study). Eur Respir J. 2007 Jul;30(1):62-5. doi: 10.1183/09031936.00121705. Epub 2007 Mar 14.

  PMID: 17360725 RESULT

• Almqvist L, Ronmark E, Stridsman C, Backman H, Lindberg A, Lundback B, Hedman L. Remission of adult-onset asthma is rare: a 15-year follow-up study. ERJ Open Res. 2020 Nov 23;6(4):00620-2020. doi: 10.1183/23120541.00620-2020. eCollection 2020 Oct.

  PMID: 33263024 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood

MeSH Terms

Conditions

Asthma; Lymphoma, Follicular

Interventions

Surveys and Questionnaires; Spirometry; Fractional Exhaled Nitric Oxide Testing

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Lymphoma, Non-Hodgkin; Lymphoma; Neoplasms by Histologic Type; Neoplasms; Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Immunoproliferative Disorders

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Diagnostic Techniques and Procedures; Diagnosis; Breath Tests

Study Officials

• Narongkorn Saiphoklang

  Thammasat University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Narongkorn Saiphoklang, MD

CONTACT

+6629269794; M_narongkorn@hotmail.com

Pacharaporn Tangsathapornpong, MD

CONTACT

+6629269701; pacharaporn.kaimook@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: December 26, 2025
• First Posted: January 8, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): October 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: IPD and documents will be available for sharing immediately after publication for a period of 2 years.

Locations

TH (1)