Effectiveness of Low -Versus High -Volume High -Intensity Interval Training in Patients With Chronic Heart Failure

NCT07325942 | Recruiting

• 1 other identifier: P.T.REC/012/005825
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

this study aims to investigate the effect of low vs high volume- high intensity interval training on functional capacity and quality of life in chronic heart failure patients

Conditions

Chronic Heart Failure

Outcome Measures

Primary Outcomes (2)

• 6 minute walk test

  self-paced submaximal field exercise test to assess submaximal functional capacity of the patient , the distance walked by the patient for six minutes will be measured by meters

  at enrolment and at the end of treatment at 8 weeks

• 2D Echocardiographic parameters

  Left ventricle geometry: left ventricular end-diastolic diameter (LVEDD) mm, left ventricular end-systolic diameter (LVESD) mm, left ventricular end-systolic volume (LVESV) ml. and, left ventricular end-diastolic volume (LVEDV) ml. Left ventricle Systolic function: left ventricular ejection fraction (LVEF) % Left ventricle Diastolic function :E wave cm/s: early diastolic mitral inflow velocity, A wave cm/s: diastolic mitral inflow velocity during late atrial contraction , E/A ratio

  at enrollment and at the end of treatment at 8 weeks

Secondary Outcomes (1)

• Minnesota living with heart failure questionnaire (MLHFQ)

  at enrollment and at the end of treatment at 8 weeks

Study Arms (3)

Low volume high intensity interval training

EXPERIMENTAL

This group will receive the usual care (standard medical treatment) in addition to LV-HIIT on a treadmill for 8 weeks, 2 sessions per week.

Other: low-volume high intensity interval training; Drug: Standard medical treatment

high volume high intensity interval training

EXPERIMENTAL

In this group, the patients will receive the usual care (standard treatment) in addition to HV-HIIT on a treadmill for 8 weeks, 2 sessions per week

Other: High volume high intensity interval training; Drug: Standard medical treatment

control group

OTHER

It includes 15 patients who will receive standard medical treatment only

Drug: Standard medical treatment

Interventions

low-volume high intensity interval training OTHER

Low-volume HIIT (LV-HIIT) is a particularly time-efficient subtype of interval training, which has gained increasing attention in recent years. As per the previous definition, these brief training protocols typically involve≤10 min of intense exercise within a session lasting≤30 min including warm-up, recovery phases between intervals, and cool-down

Low volume high intensity interval training

High volume high intensity interval training OTHER

long (2-4 min) bouts of high (not maximum) intensity exercise interspersed with recovery periods which have wide varieties in the protocols according to the intensity, duration, and number of intervals performed

high volume high intensity interval training

Standard medical treatment DRUG

standard medical treatment for chronic heart failure as per international guidlines

Low volume high intensity interval training; control group; high volume high intensity interval training

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Chronic stable heart failure patient with reduced ejection fraction (EF \<40)
• Age Above 18 years old
• Both males and females
• The ability to provide informed consent

You may not qualify if:

• Based on the Scientific Statement from the American Heart Association: contraindications for exercise Testing and Training. (Fletcher et al., 2013)
• Acute myocardial infarction (MI), within 2 days
• Ongoing unstable angina
• Uncontrolled cardiac tachy or brady arrhythmia with hemodynamic compromise
• Active endocarditis
• Symptomatic severe aortic stenosis
• Decompensated heart failure
• Acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis
• Acute myocarditis or pericarditis
• Acute aortic dissection
• Physical disability that precludes safe and adequate testing or training
• Known obstructive left main coronary artery stenosis
• Hypertrophic obstructive cardiomyopathy with severe resting gradient
• Recent stroke or transient ischemic attack
• Mental impairment with limited ability to cooperate

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, Giza Governorate, Egypt

RECRUITING

Central Study Contacts

Aya I Elshenawy

CONTACT

+01098811085; dr.aya_ebrahime@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: physical therapy specialist

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: January 8, 2026
• Study Start: December 10, 2025
• Primary Completion (Estimated): June 6, 2026
• Study Completion (Estimated): June 6, 2026
• Last Updated: January 8, 2026

Record last verified: 2026-01

Locations

EG (1)