Evaluation of Irisin Levels in Adult Forearm Fracture Surgery Under Infraclavicular Block and General Anesthesia

NCT07324681 | Not Yet Recruiting

• 1 other identifier: TABED 1-25-1099
• Study Type: interventional
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

This randomized prospective study evaluates the effect of general anesthesia versus infraclavicular nerve block on perioperative serum irisin levels in adults undergoing forearm fracture surgery. Irisin levels will be measured preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively. The association between irisin changes and fracture healing will be explored as a secondary outcome.

Conditions

Inflamation; Healing; Angiogenesis

Keywords

irisin; infraclavicular block; forearm fracture

Outcome Measures

Primary Outcomes (1)

• Change in Serum Irisin Levels

  Serum irisin levels (ng/dL) will be measured to evaluate the effect of anesthesia type on perioperative irisin response. Blood samples will be collected at three time points: preoperatively (baseline), 30 minutes postoperatively, and 24 hours postoperatively. Changes in irisin levels will be compared between the general anesthesia group and the infraclavicular block group.

  Preoperative (baseline), 30 minutes postoperatively, and 24 hours postoperatively

Secondary Outcomes (1)

• Radiological Fracture Healing and Callus Formation

  Postoperative follow-up period (up to 6 months)

Study Arms (2)

General Anesthesia (GA) Group

ACTIVE COMPARATOR

Adult patients undergoing elective forearm fracture surgery under general anesthesia. Standard noninvasive monitoring will be used and perioperative hemodynamic variables and analgesic use will be recorded. Blood samples for serum irisin will be collected preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively.

Procedure: General Anesthesia (GA)

Infraclavicular Block (ICB) Group

EXPERIMENTAL

Adult patients undergoing elective forearm fracture surgery with an ultrasound-guided infraclavicular brachial plexus block performed approximately 1 hour before surgery under monitored conditions. Standard noninvasive monitoring will be used; perioperative hemodynamic variables and analgesic use will be recorded. Blood samples for serum irisin will be collected preoperatively, at 30 minutes postoperatively, and at 24 hours postoperatively.

Procedure: Infraclavicular Brachial Plexus Blocks

Interventions

General Anesthesia (GA) PROCEDURE

General anesthesia administered according to institutional routine; anesthetic drugs and doses will be recorded.

General Anesthesia (GA) Group

Infraclavicular Brachial Plexus Blocks PROCEDURE

Ultrasound-guided infraclavicular block performed preoperatively; details of technique, local anesthetic drugs and doses will be recorded.

Infraclavicular Block (ICB) Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 to 65 years
• Scheduled for elective forearm fracture surgery
• Planned to receive either general anesthesia or infraclavicular brachial plexus block
• American Society of Anesthesiologists (ASA) physical status I-III
• Able to provide written and verbal informed consent

You may not qualify if:

• Age \<18 years or \>65 years
• Emergency surgery
• Refusal or inability to provide informed consent
• ASA physical status IV or V
• Known bone diseases or metabolic bone disorders
• Multiple trauma or associated organ injury
• Inability to mobilize
• Morbid obesity (BMI \>40 kg/m²)
• Renal failure
• Hepatic failure
• Neurological deficits or sequelae
• Contraindication or allergy to any anesthetic agents used in the study

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Related Publications (1)

• Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP, Spiegelman BM. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038/nature10777.

  PMID: 22237023 RESULT

MeSH Terms

Interventions

Anesthesia, General

Intervention Hierarchy (Ancestors)

Anesthesia; Anesthesia and Analgesia

Study Officials

• sumru sekerci, professor

  Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation, Ankara, Çankaya

  STUDY DIRECTOR

Central Study Contacts

yusuf aynigul, resident

CONTACT

+905522096781; aynigulyusuff@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 24, 2025
• First Posted: January 7, 2026
• Study Start: January 25, 2026
• Primary Completion: May 2, 2026
• Study Completion: May 5, 2026
• Last Updated: January 9, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share