Is It So Hard To Predict Complicated Diverticulitis?

NCT07322926 | Completed

• 1 other identifier: HaydarpasaNumune
• Study Type: observational
• Target: 101
• Locations: 1 country
• Sites: 1

Brief Summary

Is It So Hard To Predict Complicated Diverticulitis? Objective: Acute diverticulitis (AD) is a frequent cause of abdominal pain leading to emergency department visits. Many biomarkers have been identified to predict the risk of developing complicated diverticulitis. In our study, we aimed to reveal the sensitivity of these biomarkers in order to better differentiate uncomplicated AD from complicated ones. Methods: 101 patients who were diagnosed with AD in the emergency outpatient clinic between 2018 and 2022, registered in the database of our hospital, were evaluated retrospectively. Demographic data of the patients and laboratory results at the time of admission were evaluated. Patients were classified as having non-complicated (Group I) or complicated diverticulitis (Group II) based on the World Society of Emergency Surgery (WSES) criteria. Laboratory values at admission, including albumin, white blood cell count (WBC), C-reactive protein (CRP), neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR), were evaluated.

Conditions

Diverticulitis

Keywords

Diverticulitis; neutrophil-to-lymphocyte ratio; lymphocyte-to-monocyte ratio; emergency

Outcome Measures

Primary Outcomes (1)

• Number of participants diagnosed with complicated acute diverticulitis according to the WSES classification

  Acute diverticulitis severity will be classified using the World Society of Emergency Surgery (WSES) diverticulitis grading system based on contrast-enhanced abdominal computed tomography (CT) findings at the time of admission. Patients will be categorized as having uncomplicated diverticulitis (WSES grades 1a and 1b) or complicated diverticulitis (WSES grades 2, 3, and 4). The primary outcome is the number of participants diagnosed with complicated diverticulitis.

  Time frame is the length of stay usually between 1-14 days

Study Arms (1)

Patient with left colonic diverticulitis

no intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

101 patients who were admitted to the Haydarpaşa Numune Training and Research Hospital General Surgery Clinic with the diagnosis of first acute diverticulitis attack between the years 2018-2022 were chosen.

You may qualify if:

• Admission to the Haydarpaşa Numune Training and Research Hospital General Surgery Clinic
• First episode of acute diverticulitis
• Diagnosis confirmed by contrast-enhanced abdominal computed tomography (CT)
• Admission between 2018 and 2022
• Retrospective identification from the hospital registry system

You may not qualify if:

• Recurrent episodes of diverticulitis
• History of prior colorectal surgery
• Symptom duration longer than 7 days before admission
• Inconsistent physical examination findings with laboratory or imaging results
• Age under 18 years
• Pathologically confirmed malignancy

Sponsors & Collaborators

• Haydarpasa Numune Training and Research Hospital: lead

Study Sites (1)

Haydarpasa Numune Research and Training Hospital

Istanbul, 34668, Turkey (Türkiye)

Location

Related Publications (4)

• Chabok A, Andreasson K, Nikberg M. Low risk of complications in patients with first-time acute uncomplicated diverticulitis. Int J Colorectal Dis. 2017 Dec;32(12):1699-1702. doi: 10.1007/s00384-017-2912-7. Epub 2017 Oct 16.

  PMID: 29038965 RESULT

• Feingold D, Steele SR, Lee S, Kaiser A, Boushey R, Buie WD, Rafferty JF. Practice parameters for the treatment of sigmoid diverticulitis. Dis Colon Rectum. 2014 Mar;57(3):284-94. doi: 10.1097/DCR.0000000000000075. No abstract available.

  PMID: 24509449 RESULT

• Zaborowski AM, Winter DC. Evidence-based treatment strategies for acute diverticulitis. Int J Colorectal Dis. 2021 Mar;36(3):467-475. doi: 10.1007/s00384-020-03788-4. Epub 2020 Nov 6.

  PMID: 33156365 RESULT

• Biondo S, Golda T, Kreisler E, Espin E, Vallribera F, Oteiza F, Codina-Cazador A, Pujadas M, Flor B. Outpatient versus hospitalization management for uncomplicated diverticulitis: a prospective, multicenter randomized clinical trial (DIVER Trial). Ann Surg. 2014 Jan;259(1):38-44. doi: 10.1097/SLA.0b013e3182965a11.

  PMID: 23732265 RESULT

MeSH Terms

Conditions

Diverticulitis; Emergencies

Condition Hierarchy (Ancestors)

Diverticular Diseases; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: November 24, 2025
• First Posted: January 7, 2026
• Study Start: September 1, 2023
• Primary Completion: January 24, 2024
• Study Completion: January 25, 2024
• Last Updated: January 7, 2026

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)