Effect of Foot Reflexology On Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients

NCT07322393 | Not Yet Recruiting DMC

• 1 other identifier: DAKhan
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the effect of foot reflexology on chemotherapy-induced nausea and vomiting in breast cancer patients. Nausea and vomiting are common side effects of chemotherapy and can negatively affect patients' comfort and quality of life. Foot reflexology is a non-invasive complementary therapy that involves applying pressure to specific points on the feet. The study will compare patients who receive foot reflexology along with standard care to those who receive standard care alone, to determine whether foot reflexology helps reduce the severity of nausea and vomiting during chemotherapy.

Conditions

Chemotherapy-induced Nausea and Vomiting

Outcome Measures

Primary Outcomes (1)

• Severity of Chemotherapy-Induced Nausea and Vomiting

  The severity of chemotherapy-induced nausea and vomiting will be assessed using the Rhodes Index of Nausea, Vomiting and Retching (RINVR), a validated scale measuring the frequency, severity, and distress of nausea and vomiting. Scores range from low to high, with higher scores indicating more severe symptoms. Measurements will be recorded before and after the intervention during each chemotherapy cycle.

  From baseline to end of each chemotherapy cycle (up to four cycles, 21 days apart)

Study Arms (2)

Foot Reflexology plus Standard Care

EXPERIMENTAL

Participants in this arm will receive foot reflexology in addition to standard chemotherapy care. Foot reflexology will be administered by the researcher using a standardized technique during chemotherapy sessions. Each session will last approximately 20-30 minutes and will be provided during each chemotherapy cycle with a 21-day interval. Standard care will be provided as per hospital protocol.

Other: Foot Reflexology

Standard Care

NO INTERVENTION

Participants in this arm will receive standard chemotherapy care as per hospital protocol. No foot reflexology intervention will be provided.

Interventions

Foot Reflexology OTHER

Foot reflexology is a complementary therapy involving the application of pressure to specific reflex points on the feet associated with nausea, vomiting, relaxation, and digestion. The intervention will be administered by the researcher for 20-30 minutes during chemotherapy sessions using a standardized technique.

Foot Reflexology plus Standard Care

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Breast Cancer patients aged \>18 Patients receiving chemotherapy in curative setting

You may not qualify if:

• Patients with paraplegia. Patients with skin ulcers or wounds. Patients with psychiatric conditions. Patients with foot fractures and varicose veins. Patients with GIT and Liver Cancer

Sponsors & Collaborators

• University of Health Sciences Lahore: lead

Related Links

• Article:Effect of Foot Reflexology on Chemotherapy Induced Nausea and Vomiting among Cancer Patients
• Article: The Impact of Foot Reflexology on Nausea-Vomiting and Sleep Quality for Lung Cancer Patients Receiving Chemotherapy in Turkey

MeSH Terms

Conditions

Vomiting

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• DR. Kausar Bano, MBBS, FCPS

  Jinnah Hospital Lahore

  STUDY CHAIR

Central Study Contacts

Dania A Khan, MSN

CONTACT

+923408380021; asadamzhr93@gmail.com

Nusrat Hussain, MSN

CONTACT

+9203085182487; hussainnusrat640@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: This is an open-label study as blinding of participants and the researcher is not feasible due to the nature of the intervention.
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MSN Student

Model Details: Participants will be randomly assigned to either an experimental group receiving foot reflexology in addition to standard care or a control group receiving standard care alone. Both groups will be followed in parallel throughout the study period.

Study Record Dates

• First Submitted: December 22, 2025
• First Posted: January 7, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): August 2, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share