NCT07321964

Brief Summary

Atrial fibrillation (AF) is the most common cardiac arrythmia, associated with increased risk of stroke, heart failure, reduced quality of life (QoL), and psychological distress. This randomized controlled trial investigates the effect of MediYoga - a program incorporating deep breathing, low-intensity yoga, and meditation- on disease-specific QoL, blood pressure, and heart rate in 456 patients with paroxysmal AF. With a strong focus on sustainability, the study is fully digital: participants are recruited online, and the 12-week intervention is delivered through an application to smartphone. Additionally, the participants receive online support via Teams. Data will be collected at baseline, 3, 6, and 12 months. The primary outcome is disease specific QoL; secondary outcomes include blood pressure, heart rate, generic QoL, and psychological wellbeing. Qualitative interviews will explore patients' experiences with the intervention.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
456

participants targeted

Target at P75+ for not_applicable

Timeline
29mo left

Started Sep 2025

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress23%
Sep 2025Sep 2028

Study Start

First participant enrolled

September 1, 2025

Completed
25 days until next milestone

First Submitted

Initial submission to the registry

September 26, 2025

Completed
3 months until next milestone

First Posted

Study publicly available on registry

January 7, 2026

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2027

Expected
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2028

Last Updated

January 7, 2026

Status Verified

January 1, 2026

Enrollment Period

1.8 years

First QC Date

September 26, 2025

Last Update Submit

January 5, 2026

Conditions

Keywords

Digital Health InterventionAtrial FibrillationYogaQuality of LifeNursing

Outcome Measures

Primary Outcomes (1)

  • Arrythmia-Specific Symptoms and Health-Related Quality

    The validated form is divided into three parts: (1) evaluation of the most recent episode of arrythmia and current medication (2) assessment of symptom burden, including a 9-point symptom scale (ASTA symptom scale) with a 4-point response scale, and (3) assessment of the HRQoL using a 13-point scale (ASTA scale) with the same 4-point response scale as the symptom scale. The ASTA scale is further divided into a physical and a mental subscale. Scores range from 0 to 100, with higher scores reflecting a higher symptom burden and a worse impact on HRQoL due to arrythmia

    Baseline, and at 3 and 6 months after enrollment

Secondary Outcomes (4)

  • Health-Related Quality of Life

    Baseline, and at 3 and 6 months after enrollment

  • Mental health

    Baseline, and at 3 and 6 months after enrollment

  • Blood pressure

    Baseline, and at 3 and 6 months after enrollment

  • Pulse

    At baseline, and 3 and 6 months after enrollment

Study Arms (3)

Intervention Group I, yoga 20 minutes x3 pr week

EXPERIMENTAL
Behavioral: Yoga 20 minutes

Intervention group II, yoga 60 minutes x1 pr week

EXPERIMENTAL
Behavioral: Yoga 60 minutes

Control group

NO INTERVENTION

Treatment as usual

Interventions

Yoga 20 minutesBEHAVIORAL

The intervention consists of 60 minutes of weekly MediYoga over a 12-week period. Participants in the intervention group may choose whether they prefer to practice yoga for 20 minutes three times per week, or for 60 minutes once per week. The yoga sessions are delivered via a smartphone application, guiding participants through the sessions with both video and audio. In addition, participants are required to complete three questionnaires and measure blood pressure and heart rate at baseline, and at 3 and 6 months of follow-up.

Also known as: MediYoga, MOSI
Intervention Group I, yoga 20 minutes x3 pr week
Yoga 60 minutesBEHAVIORAL

The intervention consists of 60 minutes of weekly MediYoga over a 12-week period. Participants in the intervention group may choose whether they prefer to practice yoga for 20 minutes three times per week, or for 60 minutes once per week. The yoga sessions are delivered via a smartphone application, guiding participants through the sessions with both video and audio. In addition, participants are required to complete three questionnaires and measure blood pressure and heart rate at baseline, and at 3 and 6 months of follow-up.

Also known as: MediYoga, MOSI
Intervention group II, yoga 60 minutes x1 pr week

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Aged 18 and above
  • Diagnosed with paroxysmal atrial fibrillation
  • EHRA score at 2 or more
  • Owner of a smartphone or tablet
  • Speaking and reading Danish
  • No comorbidity that restricts them from participating in the intervention

You may not qualify if:

  • Elevated TSH Hormone
  • Participated in mindfulness or yoga exercise regularly at any point during the last two years.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Herlev and Gentofte University Hospital

Herlev, 2730, Denmark

RECRUITING

MeSH Terms

Conditions

Atrial FibrillationPsychological Well-Being

Interventions

Yoga

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsPersonal SatisfactionBehavior

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsSpiritual TherapiesExercise Movement TechniquesPhysical Therapy Modalities

Central Study Contacts

Signe S Risom, Associated Professor

CONTACT

Camilla H Johansen, Msc

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor, PhD, RN, Senior Researcher

Study Record Dates

First Submitted

September 26, 2025

First Posted

January 7, 2026

Study Start

September 1, 2025

Primary Completion (Estimated)

June 30, 2027

Study Completion (Estimated)

September 1, 2028

Last Updated

January 7, 2026

Record last verified: 2026-01

Data Sharing

IPD Sharing
Will share

Data will be shared upon reasonable request

Shared Documents
STUDY PROTOCOL, ICF

Locations