Ultra-early Chest CT for SAP Prediction

NCT07321275 | Completed DMC

• 1 other identifier: SENTRY
• Study Type: observational
• Target: 1,499
• Locations: 1 country
• Sites: 8

Brief Summary

Stroke-associated pneumonia (SAP) is a common and serious complication after acute ischaemic stroke (AIS). Existing scores rely mainly on clinical variables, and the added prognostic value of inflammatory markers and early chest CT findings remains uncertain. We developed and externally validated an early multimodal model combining clinical severity, inflammation, and chest CT abnormalities, and explored risk-stratified associations between prophylactic antibiotics and SAP.

Conditions

Acute Ischaemic Stroke; Stroke-associated Pneumonia

Keywords

Acute ischaemic stroke; Stroke-associated pneumonia; Risk prediction model

Outcome Measures

Primary Outcomes (1)

• Stroke-associated pneumonia

  SAP was defined as pneumonia occurring within 7 days after stroke onset. Potential events were screened using discharge diagnosis codes and medical record documentation, and then confirmed by manual chart review using prespecified clinical, laboratory, and radiological criteria consistent with the Pneumonia in Stroke Consensus Group and modified CDC definitions.

  within 7 days after stroke onset

Study Arms (2)

Development (Derivation) cohort

External validation cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults (≥18 years) with neuroimaging-confirmed acute ischemic stroke admitted to participating tertiary stroke centers in China. Eligibility requires chest CT performed within 24 h of stroke onset . Patients will be retrospectively identified from electronic medical records and stroke registries, and stroke-associated pneumonia will be assessed within 7 days after stroke onset using prespecified criteria. Only the first eligible admission per individual will be included.

You may qualify if:

• patients aged ≥18 years;
• Admitted to a participating stroke centre with neuroimaging-confirmed acute ischaemic stroke ;
• Had chest CT performed within 24 hours of stroke onset.

You may not qualify if:

• Pneumonia;
• Chest CT images unavailable or incomplete for assessment;
• Insufficient clinical documentation to ascertain stroke-associated pneumonia occurrence within 7 days after stroke onset

Sponsors & Collaborators

• Capital Medical University: lead

Study Sites (8)

Suzhou Municipal Hospital of Anhui Province

Suzhou, Anhui, 234000, China

Location

Rongcheng County People's Hospital

Baoding, Hebei, China

Location

Ningjin County People's Hospital

Fenghuang, Hebei, 055550, China

Location

The Second Hospital of Hebei Medical University,

Shijiazhuang, Hebei, 050061, China

Location

Central Hospital of Xiangtan

Xiangtan, Hunan, 411100, China

Location

First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, China

Location

Shihezi People's Hospital,

Shihezi, Xinjiang, 836800, China

Location

Xuanwu Hospita

Beijing, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Neurology, Xuanwu Hospital, Capital Medical University

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 7, 2026
• Study Start: January 15, 2026
• Primary Completion: February 19, 2026
• Study Completion: February 19, 2026
• Last Updated: March 10, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

CN (8)