Cardiac CT Evaluation of EAT in AF vs. Non-AF Subjects

NCT07320261 | Not Yet Recruiting

• 1 other identifier: 2025-1638-1
• Study Type: observational
• Target: 600
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this cross-sectional study is to explore the relationship between atrial structural characteristics (such as epicardial adipose tissue infiltration and atrial size) and atrial fibrillation (AF), as well as the differences in these characteristics among different AF subtypes. It will also clarify the independent association between pericardial fat distribution and AF (and its subtypes) after excluding confounding factors. The main questions it aims to answer are:

• What are the differences in epicardial adipose tissue volume and atrial size among patients with sinus rhythm, paroxysmal AF, and persistent AF?
• Is pericardial fat distribution independently associated with AF and its subtypes after adjusting for confounding factors such as age, hypertension, and left atrial enlargement? Researchers will enroll patients who undergo coronary CTA or left atrial CTA at The Second Affiliated Hospital of Zhejiang University School of Medicine, and match and divide them into three groups (sinus rhythm group, paroxysmal AF group, and persistent AF group) based on BMI and other factors. They will compare the differences in pericardial fat distribution and baseline characteristics among the three groups and analyze the independent association between pericardial fat and AF. Participants will:
• Provide relevant clinical baseline data and CTA examination results
• Complete the collection of demographic information, medical history, and laboratory test data The study duration is 6 months, starting from the date of ethical approval, with an expected end date of June 2026. A total of 600-900 participants (200-300 per group) will be enrolled to ensure the reliability and clinical applicability of the research conclusions.

Conditions

Atrial Fibrillation (AF); CT

Outcome Measures

Primary Outcomes (1)

• The difference in epicardial adipose tissue distribution among the three cohorts

  At the time of enrollment

Study Arms (3)

Paroxysmal AF

Persistent AF

Paroxysmal AF

Sinus rhythm

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients aged 18 years or older who undergo coronary CTA or left atrial CTA examination at The Second Affiliated Hospital of Zhejiang University School of Medicine. Participants will be categorized into three cohorts according to their confirmed cardiac rhythm status: sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation. All enrolled individuals must be willing to provide clinical baseline data and allow access to their CTA examination results, and be able to understand and cooperate with the study's data collection process. Patients under 18 years of age, those with incomplete clinical data or unreadable CTA images, and those who refuse to participate or cannot cooperate will be excluded from the study. The total planned sample size is 600-900 participants, with 200-300 participants in each cohort.

You may qualify if:

• Patients who undergo coronary CTA or left atrial CTA examination at The Second Affiliated Hospital of Zhejiang University School of Medicine;
• Aged 18 years or older
• Cardiac rhythm status is confirmed as sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation;
• Willing to provide clinical baseline data and allow access to CTA examination results;
• Able to understand and cooperate with the data collection process of the study.

You may not qualify if:

• Patients with incomplete clinical baseline data or unreadable CTA images;
• Aged less than 18 years
• Patients who refuse to participate in the study or cannot cooperate with data collection;

Sponsors & Collaborators

• xiaoya wang: lead
• University of Auckland, New Zealand: collaborator

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Xiaoya Wang, Doctor

CONTACT

86-0571-87784704; wxyonce@zju.edu.cn

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Chief Physician

Study Record Dates

• First Submitted: December 22, 2025
• First Posted: January 6, 2026
• Study Start: January 1, 2026
• Primary Completion: February 28, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: January 6, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Data sharing will be initiated after the primary study results are published, and the sharing period will be 3 years from the date of publication.
• Access Criteria: Researchers engaged in legitimate scientific research related to the study field (e.g., cardiovascular disease research focusing on atrial fibrillation and atrial structural characteristics) who can demonstrate the scientific relevance and feasibility of their research projects. De-identified IPD and supporting information including the study protocol, Statistical Analysis Plan (SAP), Informed Consent Form (ICF) template, Clinical Study Report (CSR), and analytic code. How to access: Interested researchers should first submit a formal application to the research team of The Second Affiliated Hospital of Zhejiang University School of Medicine, which includes a detailed research proposal, proof of institutional affiliation, and a commitment to abide by relevant ethical regulations and data use agreements. After the research team reviews and approves the application, the de-identified IPD and supporting information will be provided.