Rapid HIV, Hep C, and Syphilis Screening in a Rural Street Medicine Clinic

NCT07317687 | Not Yet Recruiting

• 1 other identifier: 2507193944
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

West Virginia faces rising rates of HIV, hepatitis, and syphilis, particularly among individuals experiencing homelessness, substance use, and mental health challenges. Traditional blood-draw testing for these infections is often hindered by mistrust, logistical barriers, and delays in results. This study, conducted by the West Virginia University (WVU) Street Medicine program, evaluates a rapid, point-of-care fingerstick test for HIV, Hepatitis C, and syphilis that provides results within 10-20 minutes during mobile clinic visits. Participants may choose rapid testing, traditional blood draw (which also includes Hepatitis B screening), or decline testing. All participants will be invited to complete a brief survey about the experiences with screening methods. The goal is to assess whether rapid testing improves screening uptake, linkage to care, and patient satisfaction, ultimately reducing barriers and disease burden in high-risk populations.

Conditions

Hepatitis B Virus (HBV); HIV Testing; HEPATITIS C (HCV); Syphilis

Keywords

Street Medicine; Rapid Fingerstick Testing

Outcome Measures

Primary Outcomes (3)

• Percentage of Finger Stick

  Percentage of participants that opted to take the rapid finger stick test.

  Day 1

• Percentage of Blood Draw

  Percentage of participants that opted to take the blood draw test.

  Day 1

• Percentage that decline screening

  Percentage of participants that opted to decline screening

  Day 1

Study Arms (3)

Participants receiving fingerstick test

* Will get a quick fingerstick test for HIV, Hepatitis C, and syphilis. * Will receive results in 10-20 minutes. * If positive, will be offered immediate care and/or a referral. * If positive, blood draw will be offered on site to confirm results or referred to a WVU Medicine clinic location for follow-up blood test. * Will be invited to answer survey questions about the feelings and experiences with screening (about 15-30 minutes).

Diagnostic Test: Rapid Fingerstick Test

Participants receiving blood-draw test

Participants receiving blood-draw test: * Will get a blood draw to test for HIV, Hepatitis B \& C, and syphilis * Will receive results in approximately 3 days (via MyChart message and phone call, or in person at site) * If positive, will be offered immediate care and/or a referral for follow-up care. • Will be invited to answer questions about the feelings and experiences with screening (about 15 minutes).

Diagnostic Test: Blood Draw for lab test

Participants who decline screening

Participants who decline screening: • Will be invited to answer survey questions about the feelings and experiences with screening (about 15-30 minutes).

Interventions

Rapid Fingerstick Test DIAGNOSTIC_TEST

Fingerstick test for HIV, Hepatitis B and C, and Syphilis that gives results within 10-20 minutes

Participants receiving fingerstick test

Blood Draw for lab test DIAGNOSTIC_TEST

Blood draw to test for HIV, Hepatitis B \& C, and syphilis which can take up to 3 days for results

Participants receiving blood-draw test

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will include patients in Berkeley and Jefferson Counties of West Virginia who visit the WVU Medicine Street Medicine Clinic.

You may qualify if:

• Patients of the WVU Medicine Street Medicine team

You may not qualify if:

• Patients under the age of 18

Sponsors & Collaborators

• West Virginia University: lead

Study Sites (1)

WVU Department of Family Medicine - Eastern Division

Harpers Ferry, West Virginia, 25425, United States

Location

MeSH Terms

Conditions

Hepatitis C; Syphilis; Hepatitis B

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Hepatitis, Viral, Human; Virus Diseases; Flaviviridae Infections; RNA Virus Infections; Hepatitis; Liver Diseases; Digestive System Diseases; Treponemal Infections; Spirochaetales Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Sexually Transmitted Diseases, Bacterial; Sexually Transmitted Diseases; Genital Diseases; Urogenital Diseases; Hepadnaviridae Infections; DNA Virus Infections

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Officials

• Madison Humerick, MD

  West Virginia University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Madison Humerick, MD

CONTACT

304-535-6343; humerickm@hsc.wvu.edu

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Department of Family Medicine - Eastern

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 5, 2026
• Study Start: January 1, 2026
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): January 1, 2028
• Last Updated: January 20, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)