Predictive Score for the Success of Discontinuation of Renal Replacement Therapy (RRT) in Intensive Care

NCT07317362 | Completed

• 1 other identifier: CSE 25-0029
• Study Type: observational
• Target: 5,976
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to evaluate when renal replacement therapy (RRT) can be safely discontinued in intensive care unit (ICU) patients with acute kidney injury (AKI). The main question it aims to answer is: Can the UNDERSCORE predictive score accurately identify ICU patients with AKI who can successfully stop RRT without needing restart or experiencing early death? Using routinely collected clinical data from the AP-HP Health Data Warehouse, the study will follow ICU patients with AKI treated with RRT to assess whether the UNDERSCORE score predicts successful RRT discontinuation within 7 days.

Conditions

D012139; D003924

Outcome Measures

Primary Outcomes (1)

• Successful weaning from renal replacement therapy

  absence of RRT resumption or death within 7 days

  7 days

Secondary Outcomes (3)

• 28-day mortality

  28 days from RRT weaning attempt

• 60 day-mortality

  Death within 60 days of RRT weaning attempt

• Renal function recovery

  7 days from RRT weaning attempt

Study Arms (1)

Study cohort

APHP adults patients (\>=18 yeays-old) admitted to the intensive care unit with severe acute kidney injury (defined as KDIGO stage 2 or 3) who received renal replacement therapy (RRT).

Other: Discontinuation of renal replacement therapy

Interventions

Discontinuation of renal replacement therapy OTHER

Discontinuation of renal replacement therapy is defined as the absence of RRT resumption within 3 days for intermittent RRT, and as definitive cessation for continuous RRT.

Study cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients admitted to the intensive care unit with severe acute kidney injury who received renal replacement therapy (RRT)

You may qualify if:

• Patients admitted to the intensive care unit with severe acute kidney injury (defined as KDIGO stage 2 or 3) who received renal replacement therapy (RRT).

You may not qualify if:

• Patients under the age of 18, those without electronical medical record

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Unité de Recherche Clinique Paris Saclay

Le Kremlin-Bicêtre, 94270, France

Location

Study Officials

• Khalil Chaibi, MD

  Medecine intensive-reanimation. Service de Réanimation médico-chirurgicale, Hôpital Avicenne, APHP, Bobigny (France)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 19, 2025
• First Posted: January 5, 2026
• Study Start: November 19, 2025
• Primary Completion: December 15, 2025
• Study Completion: December 15, 2025
• Last Updated: January 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)