Norwegian Spontaneous Coronary Artery Dissection Study

NCT07317323 | Recruiting

• 2 other identifiers: 853139ProCardio
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 3

Brief Summary

The Norwegian Spontaneous Coronary Artery Dissection Study (NOR-SCAD) is a national, multicenter prospective observational study conducted at major hospitals in Norway. The study investigates risk factors and complications of spontaneous coronary artery dissection (SCAD). Patients aged 18 years or older who are hospitalized with SCAD are recruited during the index hospitalization. Each participant will be followed for 52 weeks with scheduled visits at 8 and 12 weeks and a final phone call at 52 weeks. Evaluations include coronary CT angiography (CTA), cardiac assessments, genetic analyses, blood sampling, structured questionnaires, and a cardiopulmonary exercise test (CPET).

Conditions

SCAD; Myocardial Infarction (MI); Women

Keywords

SCAD NORGE; NOR-SCAD; Spontan Koronar arteriedisseksjon studie; Norwegian Spontaneous Coronary artery dissection study

Outcome Measures

Primary Outcomes (1)

• Major Adverse Cardiac Events

  Recurrent myocardial infarction, extra coronary dissection, stroke/TIA, heart failure,

  From enrollment to the end of follow-up at 52 weeks

Secondary Outcomes (2)

• Assessment of Quality of life

  12 weeks after event

• CTA

  Acute and after 12 weeks

Study Arms (1)

Prospective

SCAD

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Spontaneous coronary artery dissection

You may qualify if:

• Spontaneous coronary artery dissection

You may not qualify if:

• Severe kidney failure
• Severe allergic reaction to contrast

Sponsors & Collaborators

• University Hospital, Akershus: collaborator
• Sorlandet Hospital HF: collaborator
• Haukeland University Hospital, Bergen, Norway: collaborator
• Universitetssykehuset i Nord-Norge HF: collaborator
• Ullevaal University Hospital: collaborator
• Helse Stavanger HF: collaborator
• St. Olavs Hospital: collaborator
• Oslo University Hospital: lead

Study Sites (3)

Haukeland University Hospital

Bergen, Norway

RECRUITING

Akershus University Hospital

Oslo, Norway

RECRUITING

Rikshospitalet, Oslo University Hospital

Oslo, Norway

RECRUITING

Related Links

• ProCardio Home site
• NOR-SCAD

Biospecimen

Retention: SAMPLES WITH DNA

Biobank

MeSH Terms

Conditions

Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Officials

• Mette Elise Estensen, MD., PhD

  ProCardio, Kardiologisk avdeling Rikshospitalet, Oslo Univeristy Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Anna Louise Astad Sørlie, MD

CONTACT

+47 926 55 483; anloso@ous-hf.no

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Consultant Cardiologist

Study Record Dates

• First Submitted: December 5, 2025
• First Posted: January 5, 2026
• Study Start: April 1, 2025
• Primary Completion (Estimated): December 31, 2035
• Study Completion (Estimated): December 31, 2035
• Last Updated: January 5, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share

Locations

NO (3)