NCT07315997

Brief Summary

Individuals with rheumatoid arthritis (RA) have up to 2x the risk of having a heart attack compared to someone without RA. The goal of this study is to identify biomarkers that can help us do a better job of identifying individuals at risk before they develop symptoms of heart disease and start preventative treatment earlier.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for all trials

Timeline
23mo left

Started Sep 2024

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress48%
Sep 2024Mar 2028

Study Start

First participant enrolled

September 4, 2024

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

December 31, 2025

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 5, 2026

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 4, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 4, 2028

Last Updated

January 5, 2026

Status Verified

December 1, 2025

Enrollment Period

3.5 years

First QC Date

December 31, 2025

Last Update Submit

December 31, 2025

Conditions

Rheumatoid Arthritis (RAAtherosclerotic Cardiovascular Disease (ASCVD)

Keywords

CAT-RA

Outcome Measures

Primary Outcomes (1)

  • coronary artery calcium score

    Quantified coronary artery calcium score

    Cross-sectional, at baseline

Interventions

high sensitivity cardiac troponinDIAGNOSTIC_TEST

Blood measurement of high sensitivity cardiac troponin

Eligibility Criteria

Age35 Years - 79 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adult patients with rheumatoid arthritis, age 40- 79 years, with one cardiovascular risk factor and not on a statin or has a contraindication to statin therapy.

You may qualify if:

  • RA diagnosed by a rheumatologist
  • Age 40- 79
  • ≥1 ASCVD risk factor including prediabetes, hypertension, BMI \>30, current or history of cigarette smoking

You may not qualify if:

  • Patients on a statin or with a contraindication to statin, on a cholesterol absorption inhibitor, or on a PCSK9 inhibitor
  • Patients with diabetes mellitus
  • Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brigham and Womens Hospital

Boston, Massachusetts, 02115, United States

RECRUITING

MeSH Terms

Conditions

Arthritis, RheumatoidAtherosclerosis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System DiseasesArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Target Duration
2 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor of Medicine

Study Record Dates

First Submitted

December 31, 2025

First Posted

January 5, 2026

Study Start

September 4, 2024

Primary Completion (Estimated)

March 4, 2028

Study Completion (Estimated)

March 4, 2028

Last Updated

January 5, 2026

Record last verified: 2025-12

Locations

US(1)