Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage

NCT07312565 | Not Yet Recruiting

• 1 other identifier: NL-009714
• Study Type: observational
• Target: 233
• Locations: 0 countries
• Sites: N/A

Brief Summary

Rationale: Aneurysms of different types are known to be associated. In literature, concurrence of intracranial- and aortic aneurysms is described. Screening for aortic aneurysms (AA) in patients with intracranial aneurysms (IA) or aneurysmal subarachnoid haemorrhage (aSAH) could be cost-effective and of significant importance to decrease morbidity and mortality. The available literature on the association between the two types of aneurysms is sparse and in general of poor methodological quality. This protocol presents a study to more adequately evaluate the association between IA and AA. Objective: To investigate the occurrence of abdominal aortic aneurysms (AAA) in patients who experienced aSAH. Study design: This single cohort prospective study will include patients who experienced aSAH. The study participants will receive an abdominal ultrasound of the aorta to detect an AAA. Study population: aSAH patients from a prospective cohort trial in the Netherlands. Main study parameters/endpoints: The primary outcome, which will be investigated in the here above described study population, is the number of AAA detected on abdominal ultrasound. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Patients will not receive an intervention, but only a diagnostic imaging without radiation. The burden associated with this study are considered minimal and the risks negligible. An abdominal ultrasound is a non-invasive diagnostic method with no risks for the participant. The only possible existing burden to the participant is travel and appointment time with a risk of detecting an abdominal aortic aneurysm or other (occult) intra-abdominal pathologies. When an aneurysm, sub-aneurysm or other intra-abdominal pathology is detected, surveillance or treatment according to standard of care and guidelines will follow.

Conditions

Aneurysm Abdominal; Cerebral Aneurysm Ruptured

Keywords

abdominal aortic aneurysm; aneurysmal subarachnoid hemorrhage; ruptured intracranial aneurysm; prospective single cohort study; ultrasound

Outcome Measures

Primary Outcomes (1)

• Occurrence of AAA

  Main study parameter/endpoint The primary endpoint of this study will be the occurrence rate of AAA in the study population. This occurrence rate will be calculated as the proportion of all performed ultrasounds in the study group (N; %).

  1 year

Secondary Outcomes (1)

• Risk factors for AAA in aSAH patients

  1 year

Study Arms (1)

Patients with aSAH from the SPARTA trial

All aSAH patients from a large prospective cohort trial in the Netherlands will be screened for eligibility(12). The Study on Prognosis of Acutely RupTured Aneurysms (SPARTA) is an observational prospective cohort trial conducted in the Netherlands in several clinical centres. The aim of this study is to evaluate the long-term clinical outcome of aSAH patients who underwent neurosurgical- or endovascular treatment for their ruptured IA. The study has a population of around 900 patients. Because of the lethality of aSAH, a large proportion of this study population will be diseased or heavily incapacitated.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All aSAH patients from a large prospective cohort trial in the Netherlands will be screened for eligibility(12). The Study on Prognosis of Acutely RupTured Aneurysms (SPARTA) is an observational prospective cohort trial conducted in the Netherlands in several clinical centres. The aim of this study is to evaluate the long-term clinical outcome of aSAH patients who underwent neurosurgical- or endovascular treatment for their ruptured IA. The study has a population of around 900 patients. Because of the lethality of aSAH, a large proportion of this study population will be diseased or heavily incapacitated.

You may qualify if:

• In order to be eligible to participate in this study, a participant must meet all of the following criteria:
• Patient is a study subject of the trial: Study on Prognosis of Acutely RupTured Aneurysms (SPARTA)(12)
• Written informed consent
• By being a study subject of the SPARTA trial, the following criteria are applicable:
• Confirmed diagnosis of SAH on CT-scan or lumbar puncture (in the presence of a negative CT-scan)
• IA related SAH as confirmed with radiological imaging
• Age 18 years or older at presentation
• Written informed consent for the SPARTA-trial

You may not qualify if:

• A potential participant who meets any of the following criteria will be excluded from participation in this study:
• Patient is not a study subject of the SPARTA trial
• Patient has Loeys-Dietz-, Marfan- or Ehlers-Danlos syndrome

Sponsors & Collaborators

• Leiden University Medical Center: lead

MeSH Terms

Conditions

Aortic Aneurysm, Abdominal; Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Aortic Aneurysm; Aneurysm; Vascular Diseases; Cardiovascular Diseases; Aortic Diseases; Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jeroen Brouwers, MD, PhD

  Leiden University Medical Centre

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Alexander Hamming, MD

CONTACT

+31655322609; a.hamming@haaglandenmc.nl

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 2, 2025
• First Posted: December 31, 2025
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04