H. Pylori Infection and AIP Levels

NCT07306377 | Completed

• 1 other identifier: Helicobacter Pylori and AIP
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Helicobacter pylori is a common bacterial infection of the stomach that can cause ulcers and other digestive problems. Recent studies suggest that this infection may also affect metabolism and blood fats (lipids), which are important for heart health. Changes in lipid levels, such as higher triglycerides and lower "good" cholesterol (HDL), can increase the risk of cardiovascular disease. This study will examine whether H. pylori infection is linked to changes in lipid profiles, especially the Atherogenic Index of Plasma (AIP). AIP is a calculation based on triglycerides and HDL cholesterol that helps predict the risk of heart disease.

Conditions

H Pylori Infection; Atherogenic Plasma Index

Outcome Measures

Primary Outcomes (1)

• Atherogenic Index of Plasma (AIP)

  AIP is calculated as log10(triglycerides/HDL cholesterol).

  Baseline (single fasting blood sample at enrollment).

Study Arms (2)

Group 1A: H. pylori Positive - Normal AIP Group 1B: H. pylori Positive - Elevated AIP Group 2: H.

Diagnostic Test: urea breath test

Group 1A: H. pylori Positive - Normal AIP, 1B: H. pylori Positive - Elevated AIP, Group 2: H.

Diagnostic Test: urea breath test

Interventions

urea breath test DIAGNOSTIC_TEST

Participants will undergo a urea breath test to confirm H. pylori infection status. Fasting blood samples will be collected to measure triglycerides and HDL cholesterol, and the Atherogenic Index of Plasma (AIP) will be calculated.

Group 1A: H. pylori Positive - Normal AIP Group 1B: H. pylori Positive - Elevated AIP Group 2: H.; Group 1A: H. pylori Positive - Normal AIP, 1B: H. pylori Positive - Elevated AIP, Group 2: H.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients (≥18 years) attending the Gastroenterology Unit at Tanta University Hospitals (Egypt) and the Internal Medicine Department at Tadawi Hospital (Saudi Arabia). Participants will include both men and women diagnosed with or without H. pylori infection, recruited consecutively during routine clinical visits.

You may qualify if:

• Patients older than 18 years.
• Able to sign the written consent.

You may not qualify if:

• Unwilling to participate in the study.
• History of severe metabolic disorders.
• Taking medications that affect adipose tissue metabolism.
• History of gastric surgery.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Faculty of Medicine

Tanta, Egypt

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Tropical Medicine and Infectious Diseases

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: December 29, 2025
• Study Start: January 2, 2025
• Primary Completion: February 18, 2025
• Study Completion: August 4, 2025
• Last Updated: December 29, 2025

Record last verified: 2025-12

Locations

EG (1)