Prevalence of Abnormal Haemoglobin Variants in Metropolitan Chattogram, Bangladesh

NCT07305181 | Completed DMC

• 1 other identifier: BBMH/2021/RP-2330
• Study Type: observational
• Target: 8,400
• Locations: 1 country
• Sites: 1

Brief Summary

Hemoglobinopathies are inherited disorders that affect haemoglobin and pose a considerable global health challenge. This research addresses the knowledge gap regarding the prevalence of a typical haemoglobin fraction within urban populations by testing the HbA1c test in capillary electrophoresis. Participants will be recruited with careful ethical considerations and informed consent will be obtained. The screening will utilize laboratory techniques to detect abnormal haemoglobin fractions through testing. Statistical methods will be used for data analysis to assess prevalence rates and pinpoint specific haemoglobin variants while considering demographic factors. The project's milestones include planning the study, collecting data (from January 2021 to June 2025), conducting analyses, preparing reports and sharing the findings.

Conditions

HbE Trait; Hemoglobinopathies

Keywords

HbE Disease; Thalassemia; Sickle cell disease

Outcome Measures

Primary Outcomes (1)

• Prevalence of abnormal haemoglobin fractions in Chattogram

  The proportion of participants identified with abnormal haemoglobin fractions.

  Day 01, at enrolment

Secondary Outcomes (1)

• Different spectrum of haemoglobin variants

  Day 01, on enrolment

Study Arms (1)

No Intervention (Diagnostic Test Only)

Biochemical Test and detect hemoglobin variants (HPLC, CE)

Eligibility Criteria

• Age: 1 Month - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will comprise individuals residing within the metropolitan area who meet the predefined inclusion criteria. Eligible participants, irrespective of age or sex, will be considered for enrollment, ensuring representation across demographic groups. Participation will be strictly voluntary, and only those who provide informed consent (or assent with parental/guardian consent in the case of minors) will be included in the study. This approach is intended to capture a diverse and representative sample of the target community, thereby enhancing the generalizability and validity of the study findings.

You may qualify if:

• Residents of the selected metropolitan area.
• All ages (1 Month - 70 Years) and both sexes.
• Willing to provide informed consent.

You may not qualify if:

• Refusal to provide informed consent.
• Inaccurate data.

Sponsors & Collaborators

• Bangladesh Bioscience Research Group: lead
• Chattogram International Dental College: collaborator
• Chittagong Medical College and Hospital: collaborator
• Bangladesh Medical University: collaborator

Study Sites (1)

University of Science and Technology Chittagong (USTC)

Khulshi, Chattogram, 4203, Bangladesh

Location

MeSH Terms

Conditions

Hemoglobinopathies; Thalassemia; Anemia, Sickle Cell

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: NETWORK
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lab-Incharge (Biochemist)

Study Record Dates

• First Submitted: December 12, 2025
• First Posted: December 26, 2025
• Study Start: January 1, 2021
• Primary Completion: June 30, 2025
• Study Completion: September 30, 2025
• Last Updated: December 26, 2025

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share

Locations

BA (1)