To Evaluate the Safety and Efficacy of RNK08954 in Patients With Metastatic Pancreatic Ductal Adenocarcinoma.

NCT07303465 | Recruiting Phase 2

• 1 other identifier: RNK08954-05
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

This is a multicenter, open-label, phase Ⅱa study to explore the safety, tolerability, and preliminary efficacy of RNK08954 in metastatic pancreatic ductal adenocarcinoma harboring a KRAS G12D mutation.

Conditions

KRAS G12D Mutations; Pancreatic Ductal Adenocarcinoma (PDAC)

Outcome Measures

Primary Outcomes (1)

• PFS

  Progression-free survival (PFS) is assessed by investigators using RECIST 1.1 criteria.

  up to 2 years

Secondary Outcomes (5)

• ORR

  up to 2 years

• DOR

  up to 2 years

• DCR

  Up to 2 years

• AEs

  Up to 2 years

• AUC

  Up to 12 months

Study Arms (1)

RNK08954

EXPERIMENTAL

Drug: RNK08954

Interventions

RNK08954 DRUG

RNK08954 will be administered at the assigned dose level, orally, until disease progression or intolerable toxicity.

RNK08954

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• The subjects voluntarily joined the study and signed the informed consent, with good compliance and follow-up.
• Male and female subjects aged 18-75 years (including 18 and 75 years).
• Pancreatic ductal adenocarcinoma confirmed by pathology (histology) or cytology.
• At the time of study enrollment, according to the solid tumor efficacy evaluation criteria (RECIST1.1), imaging diagnosis had at least one measurable lesion .
• Presence of a KRAS G12D mutation.
• Physical condition score ECOG score 0-1 points.
• Expected survival ≥ 12 weeks.
• Have adequate hematologic and end-organ function, with laboratory test results within required parameters within 7 days prior to the first dose.
• Fertile female subjects and male subjects whose partners are women of reproductive age must agree to comply with the contraceptive requirement from the time of signing the informed consent until 6 months after the final administration of the trial drug.Fertile female subjects must undergo a serum pregnancy test within 7 days before the first dose, and the result is negative; And must be non-lactating.

You may not qualify if:

• Diagnosed with other pathological types of pancreatic tumors;
• Presence of uncontrolled symptomatic central nervous system metastases; including leptomeningeal metastasis, spinal cord metastasis, or brainstem metastasis.
• Presence of symptomatic, moderate or greater fluid accumulation in serous cavities (e.g., pleural effusion, ascites, pericardial effusion) which either necessitates therapeutic intervention or is judged by the investigator to make the patient ineligible.
• Clinical condition with an acute and significant decline, including, but not limited to, a decrease in ECOG performance status to \>1 within 72 hours prior to the baseline visit and initiation of study treatment, a weight loss of ≥10% during the screening period, or a BMI \<18.0 kg/m²
• History of known severe or uncontrolled cardiovascular or cerebrovascular disease that requires treatment.
• The patient had previously used KRAS inhibitors or pan-KRAS inhibitors therapy.
• Received systemic anti-tumor therapy prior to the first dose, or received Chinese herbal preparations with clear anti-pancreatic tumor indications within 2 weeks before the first dose.
• Having received other investigational drugs or therapies not yet approved for marketing prior to the first dose, with the interval from the last administration or treatment being less than 4 weeks or 5 half-lives (whichever is shorter).
• Having undergone major surgery or experienced significant trauma within 4 weeks prior to the first dose, or requiring elective surgery during the trial period.
• The presence of severe non-healing wounds, ulcers, fractures, etc., within 4 weeks prior to the first dose.
• Severe infection occurred within 4 weeks prior to the first dose, including but not limited to hospitalization due to infectious complications, bacteremia, or severe pneumonia; presence of systemic active infection within 2 weeks prior to the first dose requiring systemic anti-infective therapy.
• Presence of active tuberculosis infection at the time of screening.
• Positive for hepatitis B surface antigen (HBsAg) at screening with hepatitis B virus (HBV) deoxyribonucleic acid (DNA) ≥ 2000 IU/mL or 10⁴ copies/mL (however, subjects can be enrolled if their HBV-DNA is \<2000 IU/mL or 10⁴ copies/mL after antiviral therapy).
• Positive for hepatitis C antibody (HCV-Ab) and positive for hepatitis C virus (HCV) ribonucleic acid (RNA) at screening.
• Known infection with human immunodeficiency virus (HIV) or active Treponema pallidum, except under certain circumstances.

Sponsors & Collaborators

• Ranok Therapeutics (Hangzhou) Co., Ltd.: lead

Study Sites (2)

Nanjing Tianyinshan Hospital

Nanjing, China

RECRUITING

Shanghai GoBroad Cancer Hospital China Pharmaccutical University

Shanghai, China

RECRUITING

Study Officials

• ShuKui Qing, MD

  Nanjing Tianyinshan Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xin Wu

CONTACT

+86 0571 8663 0936; xinwu@ranoktherapeutics.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2025
• First Posted: December 24, 2025
• Study Start: October 14, 2025
• Primary Completion (Estimated): November 30, 2026
• Study Completion (Estimated): November 30, 2026
• Last Updated: December 24, 2025

Record last verified: 2025-12

Locations

CN (2)