Prevalence of Sarcopenia in Patients Admitted to ICU and Its Progression During Hospitalization.

NCT07303335 | Enrolling By Invitation

• 2 other identifiers: P/25-054/Fundació assistencialMutua Terrassa
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This is a prospective, observational study at the ICU of Hospital Mútua de Terrassa, running from May to December 2025. The primary goal is to determine the prevalence of sarcopenia in adult patients requiring more than 48 hours of mechanical ventilation. Sarcopenia is assessed using the SARC-F score, impedanciometry, and quadriceps ultrasound. Secondary aims include tracking the development of ICU-Acquired Weakness (ICU-AW) using the MRC score. All data is collected anonymously after obtaining informed consent.

Conditions

Sarcopenia; Critical Illness; Intensive Care (ICU) Myopathy; Body Composition Measurement; Bio-Impedance Measurements; Ultrasound Evaluation

Outcome Measures

Primary Outcomes (1)

• Prevalence of sarcopenia at the time of ICU admission.

  Describe the prevalence of sarcopenia at the time of ICU admission in patients with an expected duration of mechanical ventilation (MV) exceeding 48 hours.

  Baseline at admission to ICU

Secondary Outcomes (2)

• Detecting patients who develop ICU-Acquired Weakness (ICU-AW) and/or prolonged mechanical ventilation weaning

  From ICU admission to 30 days follow-up

• Detecting the appearance of other complications

  From admission to 30 days follow up

Study Arms (1)

Critically ill adults (medical or surgical) expected to require prolonged mechanical ventilation.

Assesment of the body composition using Rectus Femoris (RF) Ultrasound and Bioelectrical Impedance Analysis (BIA)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to a polyvalent (medical and surgical) ICU.

You may qualify if:

• Older than 18 years old.
• Expected duration of mechanical ventilation (MV) exceeding 48 hours.

You may not qualify if:

• Refusal to participate.
• Mechanical ventilation not exceeding 48 hours.
• Do-not-resuscitate (DNR) orders or limitations of therapeutic effort upon admission.

Sponsors & Collaborators

• Hospital Mutua de Terrassa: lead

Study Sites (1)

Hospital Universitari Mútua Terrassa

Terrassa, Barcelona, 08012, Spain

Location

Related Publications (2)

• Sostakaite G, Jauniskyte M, Budrys D, Budrevicius K, Salciute-Simene E, Svetikiene M, Jovaisa T, Zvirblis T, Klimasauskas A, Sipylaite J. Comparison of Two Techniques to Assess Muscle Mass Loss During ICU Stay: Muscle Ultrasound vs Bioelectrical Impedance Analysis. Nutrition. 2025 Feb;130:112607. doi: 10.1016/j.nut.2024.112607. Epub 2024 Oct 24.

  PMID: 39549651 BACKGROUND

• Nakanishi N, Tsutsumi R, Okayama Y, Takashima T, Ueno Y, Itagaki T, Tsutsumi Y, Sakaue H, Oto J. Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices. J Intensive Care. 2019 Dec 16;7:61. doi: 10.1186/s40560-019-0416-y. eCollection 2019.

  PMID: 31890223 BACKGROUND

MeSH Terms

Conditions

Sarcopenia; Critical Illness; Muscular Diseases

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Disease Attributes; Pathologic Processes; Musculoskeletal Diseases; Neuromuscular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 4 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 17, 2025
• First Posted: December 24, 2025
• Study Start: May 14, 2025
• Primary Completion: December 31, 2025
• Study Completion: February 1, 2026
• Last Updated: December 24, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF

Locations

ES (1)