Effect of Double Nutri® Liposomal Encapsulation Technology on Human Absorption of Vitamin C and Glutathione Liquid Sachet

NCT07302828 | Completed

• 1 other identifier: 25-098-A
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to evaluate whether Double Nutri® liposomal encapsulation technology can enhance the oral absorption of liquid vitamin C and glutathione supplements in humans.

Conditions

Vitamin C; Glutathione

Keywords

vitamin c; glutathione; liposomal; human bioavailability; Double Nutri

Outcome Measures

Primary Outcomes (2)

• Blood vitamin C level (ug/mL)

  Blood vitamin C levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.

  at 8 hours after taking test sample

• Blood glutathione level (μmol/L)

  Whole blood glutathione levels will be measured at fasting and at 0.5, 1, 2, 4, 6, and 8 hours post-intake.

  at 8 hours after taking test sample

Study Arms (2)

Vitamin C and Glutathione without liposome

ACTIVE COMPARATOR

Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione

Dietary Supplement: Vitamin C and Glutathione without liposome

Liposomal Vitamin C and Glutathione

EXPERIMENTAL

Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the test sample is processed using the Double Nutri liposomal technology

Dietary Supplement: Liposomal Vitamin C and Glutathione

Interventions

Vitamin C and Glutathione without liposome DIETARY_SUPPLEMENT

Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione.

Vitamin C and Glutathione without liposome

Liposomal Vitamin C and Glutathione DIETARY_SUPPLEMENT

Each administration consists of two sachets, with each sachet containing 1,000 mg of vitamin C and 60 mg of glutathione, and the product is processed using the Double Nutri liposomal technology.

Also known as: GLUTA BRIGHT, Double Nutri Vitamin C and Glutathione

Liposomal Vitamin C and Glutathione

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older, of any sex, who are willing to sign the informed consent form and are able to fully comply with all study procedures.

You may not qualify if:

• Pregnant or breastfeeding women, or individuals unwilling to use physical contraceptive methods during the study period, such as condoms or intrauterine devices (IUDs).
• Employees of TCI Co., Ltd and their family members.
• Individuals who, within 30 days prior to study initiation, have been taking vitamin C supplements at doses greater than 200 mg per day, glutathione supplements at doses greater than 100 mg per day, or medications that may affect endogenous vitamin C or glutathione levels, such as oral contraceptives and estrogen preparations (including ethinylestradiol, desogestrel, gestodene, drospirenone, cyproterone acetate), or acetaminophen.
• Individuals with chronic gastrointestinal diseases (including irritable bowel syndrome \[IBS\], inflammatory bowel disease \[IBD\], chronic diarrhea, Crohn's disease, celiac disease, bowel control disorders/fecal incontinence, pancreatitis, peptic ulcer disease, colorectal cancer, short bowel syndrome, and ulcerative colitis), a history of epilepsy or seizures, liver or kidney disease, malignancy, endocrine disorders, psychiatric disorders, alcohol or drug abuse, or other significant organic diseases based on medical history.
• Individuals who have undergone gastrointestinal surgery, organ transplantation, or other major surgical procedures.
• Individuals who experienced acute gastroenteritis within two weeks prior to study initiation.
• Individuals with a known allergy to any components of the testing samples.

Sponsors & Collaborators

• TCI Co., Ltd.: lead

Study Sites (1)

TCI Co., Ltd

Taipei, 114, Taiwan

Location

MeSH Terms

Interventions

Ascorbic Acid; Glutathione; Liposomes

Intervention Hierarchy (Ancestors)

Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates; Oligopeptides; Peptides; Amino Acids, Peptides, and Proteins; Membranes, Artificial; Biomedical and Dental Materials; Drug Carriers; Dosage Forms; Pharmaceutical Preparations; Manufactured Materials; Technology, Industry, and Agriculture; Biomimetic Materials

Study Officials

• Tong-Lin Wu

  TCI Co., Ltd.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2025
• First Posted: December 24, 2025
• Study Start: December 15, 2025
• Primary Completion: January 16, 2026
• Study Completion: February 2, 2026
• Last Updated: February 3, 2026

Record last verified: 2026-02

Locations

TW (1)