Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions

NCT07302503 | Recruiting

• 1 other identifier: 9451
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football. Soccer, due to repeated headers, could also be associated, albeit to a lesser degree, with the development of this type of pathology. Indeed, it has been shown that playing soccer can be accompanied by cognitive impairments, and neurodegenerative brain abnormalities have been described in neuropathology studies of former professional soccer players. Subradiological brain abnormalities have been found in multimodal MRI in various sports. Similarly, a decrease in cognitive performance has been described. The discovery of this type of anomaly in a population of professional footballers nearing the end of their careers could lead to:

• The implementation of appropriate monitoring for professional footballers through early detection of lesions via MRI and cognitive disorders
• The implementation of preventative measures for professional footballers, but also for amateur footballers from a very young age.

Conditions

Chronic Traumatic Encephalopathy

Keywords

Chronic Traumatic Encephalopathy; Post-traumatic lesions; Neurodegenerative brain abnormalities; Professional soccer players

Outcome Measures

Primary Outcomes (1)

• Changes found in MRI diffusion tensor imaging of professional football players

  day 1 post-consultation

Eligibility Criteria

• Age: 32 Years - 60 Years
• Sex: male
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Male subject aged 32 to 60 years

You may qualify if:

• Male subject
• Aged 32 to 60 years inclusive
• Professional footballer nearing the end of their career or recently retired, or subject who has never regularly participated in sports that expose them to head trauma (particularly rugby, basketball, handball, American football, hockey, combat sports, etc.)

You may not qualify if:

• \- Subject who expressed their opposition to participating in the study

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service d'Imagerie 2 - Réanimation - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Chronic Traumatic Encephalopathy

Condition Hierarchy (Ancestors)

Brain Injuries, Traumatic; Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Brain Injury, Chronic; Neurodegenerative Diseases; Craniocerebral Trauma; Trauma, Nervous System; Brain Damage, Chronic; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Wounds and Injuries

Central Study Contacts

Stéphane KREMER, MD, PhD

CONTACT

33 3 88 12 78 48; stephane.kremer@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 10, 2025
• First Posted: December 24, 2025
• Study Start: September 10, 2024
• Primary Completion (Estimated): March 1, 2028
• Study Completion (Estimated): March 1, 2028
• Last Updated: December 24, 2025

Record last verified: 2025-12

Locations

FR (1)