Study of a Cohort of Non-HIV Immunocompromised Patients With Toxoplasmosis at the Strasbourg University Hospital

NCT07299500 | Recruiting

• 1 other identifier: 9375
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Toxoplasmosis in HIV-positive individuals is well-studied and has a codified management protocol, which is not the case for other immunodeficiencies, except for recent recommendations in the context of hematopoietic stem cell transplantation. A description of this population is necessary to estimate the number of patients affected and to define their specific management (diagnosis, treatment, prevention).

Conditions

Cerebral Toxoplasmosis

Keywords

Cerebral toxoplasmosis; HIV; Immunodeficiencies; Hematopoietic stem; stem cell transplantation

Outcome Measures

Primary Outcomes (1)

• Overall patient survival rates

  Up to 1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult subject (≥18 years) with a positive toxoplasmosis PCR test (regardless of tissue)

You may qualify if:

• Adult (≥18 years)
• Immunocompromised (i.e., solid organ transplant recipient, hematological malignancy, cancer patient, patient treated with immunosuppressive therapy or therapy affecting the immune system by any mechanism, hematopoietic stem cell transplant recipient, patient with an autoimmune disease or immunodeficiency, whether primary or secondary).
• At least one positive toxoplasmosis PCR test (regardless of tissue)

You may not qualify if:

• Subject who has expressed opposition to the reuse of their data for scientific research.
• HIV positive
• Congenital toxoplasmosis
• Isolated ocular toxoplasmosis in immunocompetent individuals

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service d'immunologie clinique - Hôpitaux Universitaires de Strasbourg

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Toxoplasmosis, Cerebral; Immunologic Deficiency Syndromes

Condition Hierarchy (Ancestors)

Brain Abscess; Central Nervous System Infections; Infections; Central Nervous System Protozoal Infections; Central Nervous System Parasitic Infections; Parasitic Diseases; Toxoplasmosis; Coccidiosis; Protozoan Infections; Abscess; Suppuration; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Immune System Diseases

Central Study Contacts

Mathilde HERBER, MD

CONTACT

33 3.69.55.13.99; mathilde.herber@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2025
• First Posted: December 23, 2025
• Study Start: February 2, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 25, 2026
• Last Updated: December 23, 2025

Record last verified: 2025-12

Locations

FR (1)