NCT07298967

Brief Summary

The purpose of this observational study is to compare the effectiveness of air surveillance and to better understand the relationship between household transmission and viruses detected in the air. Participants will provide nasal swabs and have an air sample surveillance device installed in their home.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
422

participants targeted

Target at P75+ for not_applicable

Timeline
1mo left

Started Jan 2026

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress83%
Jan 2026Jun 2026

First Submitted

Initial submission to the registry

December 19, 2025

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 23, 2025

Completed
15 days until next milestone

Study Start

First participant enrolled

January 7, 2026

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2026

Last Updated

January 22, 2026

Status Verified

December 1, 2025

Enrollment Period

5 months

First QC Date

December 19, 2025

Last Update Submit

January 21, 2026

Conditions

Influenza-like IllnessAcute Respiratory Infection

Outcome Measures

Primary Outcomes (7)

  • Rate of virus detection

    Participants will provide nasal swabs, which will be tested for a panel of viruses.

    Day 0, Day 7, Day 14

  • Rate of air sampling detection among families with documented transmission

    Study team will collect and test air sampler filter for viruses.

    Day 7, Day 14

  • Rate of air sampling detection among families without documented transmission

    Study team will collect and test air sampler filter for viruses.

    Day 7, Day 14

  • Survey of symptoms - day 0

    Qualitative survey of participants' symptoms and related activities.

    Day 0

  • Survey of symptoms - day 7

    Qualitative survey of participants' symptoms and related activities.

    Day 7

  • Survey of symptoms - day 14

    Qualitative survey of participants' symptoms and related activities.

    Day 14

  • Air sampler use survey

    Qualitative survey about participants' use of the air sampler.

    Day 7, Day 14

Secondary Outcomes (1)

  • Number of absences

    14 days

Study Arms (1)

Students with ARI (acute respiratoy infection)

EXPERIMENTAL

Students with ARI and their household members will provide nasal swabs

Diagnostic Test: Nasal swabDevice: Indoor air quality monitor

Interventions

Indoor air quality monitorDEVICE

InBio Apollo ambient air sampler to be run in the home for the duration of study participation. Material from the air, like aerosols, dust particles, and other environmental material, are collected on sampler filler material.

Students with ARI (acute respiratoy infection)
Nasal swabDIAGNOSTIC_TEST

Participants will use a swab to collect nasal specimens

Students with ARI (acute respiratoy infection)

Eligibility Criteria

Age4 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Student attends, or is eligible to attend, a school within the Oregon School District (OSD)
  • Study has an illness characterized by at least 2 of 6 acute respiratory infection (ARI)/ILI symptoms (nasal discharge, nasal congestion, sneezing, sore throat, cough, fever) and student scores at least 2 points on the Jackson scale

You may not qualify if:

  • Household member listed on Wisconsin Department of Corrections Sex Offender Registry
  • Illness onset more than 7 days before anticipated time of specimen collection
  • Anatomical defect for which nasal specimen collection is contraindicated
  • Student participated too recently (\<7 days from day 14 during peak influenza / COVID-19 period and \<30 days during other times, as determined by a medically-attended surveillance program)
  • Live in the same household as eligible student participant
  • Any age and gender
  • Fluent in English
  • Able to provide appropriate consent or assent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Wisconsin-Madison

Madison, Wisconsin, 53705, United States

RECRUITING

Study Officials

  • Jonathan Temte, MD, PhD

    University of Wisconsin, Madison

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Shari Barlow

CONTACT

608-265-4348shari.barlow@fammed.wisc.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 19, 2025

First Posted

December 23, 2025

Study Start

January 7, 2026

Primary Completion (Estimated)

June 1, 2026

Study Completion (Estimated)

June 1, 2026

Last Updated

January 22, 2026

Record last verified: 2025-12

Data Sharing

IPD Sharing
Will share

Locations

US(1)