To Compare the Effect of Closed Kinetic Chain and Isometric Exercises in Reducing Pain and Improving Functional Disability in Patients With Patellofemoral Pain Syndrome Associated With Knee Osteoarthritis

NCT07298798 | Active Not Recruiting

• 1 other identifier: IRB4014/DUHS/Approval/2025/268
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Investigator study aims to compare the benefits of isometric exercise and closed kinetic chain exercises in strengthening programs to lessen pain along with enhance functionality in patients with PFP that are being associated with osteoarthritis and the assessment of PFP pertains to its recognition and the determination of significant therapeutic techniques. 70 Participants from the department of physiotherapy, Civil Hospital Karachi CHK and Dow University of Health Science (DIPMR) will be randomly assigned into two groups, an experimental group receiving closed kinetic chain exercise, and a control group receiving isometric exercises. The therapy will last four weeks, consisting of twelfth sessions. There will be 35 to 40 minutes in each session, Patients will be evaluated on primary outcome measure, pain intensity and functional limitation using various scales, including the numerical pain rating scale (NPRS) and Kujala/anterior knee pain scale (AKPS)

Conditions

Knee Osteoarthritis

Outcome Measures

Primary Outcomes (2)

• numerical pain rating scale (NPRS)

  1\. Numerical pain rating scale (NPRS) Pain intensity will measure using NPR scale (no need for permission), a reliable instrument retest reliability of 0.95 , 0 represents no pain and 10 represents severe suffering. 10= indicate worse pain 5= indicate moderate pain 0 = indicate no pain.

  12th sessions for four weeks ,outcome measures will take place both, at the baseline when intervention start and four weeks, following the intervention

• . Kujala/ Anterior knee pain scale (AKPS)

  we will use the Kujala scale to measure functional limitations, a reliable instrument retest reliability of 0.9 in patient with PFPS, total 13 self-reported questionnaire. AKPS graded 0 to 100, 100 being the highest possible score with no pain and disability. Lower scores reflect greater pain and disability.

  12th sessions for four weeks, ,outcome measures will take place both, at the baseline when intervention start and four weeks, following the intervention

Study Arms (2)

GroupA . given treatment closed kinetic chain exercise

EXPERIMENTAL

Terminal knee extension, The patient stand facing the plinth with feet shoulder-width apart and a theraband looped around their knee and other plinth legs. patient bend their knees to a 30-degree angle, extend their leg against the band's resistance, and hold this position for six seconds. VMO squat, The position of patient, hip and knee will bend, weight of the body on feet and feet about shoulder width apart and turn the feet outward about 45 degrees and position hold for 30 second.

Behavioral: Terminal knee extension. .VMO squat. [TheraBand]

GroupB . given treatment isometric exercise SLR, Static quads.

EXPERIMENTAL

Static Quads The patient is long sitting or supine on their back, with a foam roll or towel behind their knee. Contract your quadriceps muscles while pressing down on the towel, maintaining this position for five seconds. Straight leg raising (SLR) The patient will be laying in supine, and before the exercise's lifting phase, a maximal isometric quadriceps contraction will be executed, followed by raising the leg to a height of 10cm above the plinth for 10 seconds.

Behavioral: Isometric exercises [knee roller]

Interventions

Terminal knee extension. .VMO squat. [TheraBand] BEHAVIORAL

Terminal knee extension, The patient stand facing the plinth with feet shoulder-width apart and a theraband looped around their knee and other plinth legs. They bend their knees to a 30-degree angle, extend their leg against the band's resistance, and hold this position for six seconds. VMO squat, The position of patient, hip and knee will bend, weight of the body on feet and feet about shoulder width apart and turnthe feet outward about 45 degrees and position hold for 30 second.

GroupA . given treatment closed kinetic chain exercise

Isometric exercises [knee roller] BEHAVIORAL

Static Quads The patient is long sitting or supine on their back, with a foam roll or towel behind their knee. Contract your quadriceps muscles while pressing down on the towel, maintaining this position for five seconds. Straight leg raising (SLR) The patient will be laying in supine, and before the exercise's lifting phase, a maximal isometric quadriceps contraction will be executed, followed by raising the leg to a height of 10 cm above the plinth for 10 seconds.

GroupB . given treatment isometric exercise SLR, Static quads.

Eligibility Criteria

• Age: 35 Years - 60 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between (35 to 60) years.
• Gender: female.
• The numerical pain rating scale (NPRS) is greater than three out often i.e. 3/10 score.
• Patient experiences anterior knee pain due to such activities like squatting, prolonged sitting, running and stair climbing.
• Patient with unilateral or bilateral knee pain with positive radiographic imaging.
• Patients have grade 1 and 2 knee osteoarthritis (K\&L classification).

You may not qualify if:

• Any past record of knee surgery.
• Any past record of knee fracture.
• Patients with any neurological disorder.
• Cancer, malignancy or any bone tumor.
• Comorbid like diabetes mellitus.
• Any systemic inflammatory arthritis.

Sponsors & Collaborators

• Dow University of Health Sciences: lead

Study Sites (1)

Saddar

Karachi, Pakistan

Location

Related Links

• Efficacy of electromyographic-biofeedback supplementation training with patellar taping on quadriceps strengthening in patellofemoral pain syndrome among young adult male athletes
• McConnell patellar taping on postural control of women with patellofemoral pain syndrome

MeSH Terms

Conditions

Osteoarthritis, Knee

Interventions

Exercise

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Experimental: GroupA .will be give treatment closed kinetic chain exercise i.e Terminal knee extension and VMO squat. GroupB .will be give treatment isometric exercise i.e SLR and Static quads.

Study Record Dates

• First Submitted: August 26, 2025
• First Posted: December 23, 2025
• Study Start: November 9, 2023
• Primary Completion: February 28, 2026
• Study Completion (Estimated): November 8, 2027
• Last Updated: January 6, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)